Stem Cell Therapy Model To Treat Diseases Of The Nervous System

Stem Cell Model To Treat Diseases Of The Nervous System

It wasn’t until the discovery of stem cell therapy that the treatment of neurodegenerative disease was believed to be an impossible event. Hence, any disease pertaining to the nervous system, including cancer, congenital disorders, and degenerative diseases such as Parkinson’s disease and Alzheimer’s disease and multiple sclerosis including traumatic diseases were among the incurable diseases. However, the tissue reparative and regeneration potentials of stem cells had removed the roadblocks to expanding the treatment scopes of replacement therapy for scientists.

Stem Cell Therapy Disease Modeling

Based on thousands of clinical studies and research works on stem cells and its disease treating potentials, the stem cell therapy transplantation proves to be life-saving for many chronic and life-threatening diseases like cancers, amyotrophic lateral sclerosis. Now, a new research has proved that monitoring the mechanisms of various nervous system diseases like Parkinson’s disease and Alzheimer’s disease is possible with the stem therapy cell model. Previously, this is what has been an unimaginable phenomenon for many.

Now, treating any disease related to the nervous system is easier, since scientists for the first time have discovered a novel method to monitor the disease using stem cells.
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• Stem Cell Therapy To Reduce The Protein Functions In The Brain Of Alzheimer’s

This disease modeling is helpful in determining the etiologies of the diseases and find treatment options for varied neurodegenerative diseases like Parkinson’s, Alzheimer’s and sclerosis. A team of scientists at City of Hope National Medical Center has discovered a model of stem cells to evaluate the disease types of the nervous system. This disease model is helpful in suppressing the actions of Alzheimer’s disease, including various neurodegenerative diseases.

In order to find the efficacy of the disease modeling, the scientists monitored Alexander disease- a similar kind of a nervous system disorder like that of Alzheimer’s.

Stem Cell Therapy Model To Detect The Mechanism Of Neurodegenerative Disease

In order to identify how neurological disease works and hinders one’s mental strength, they examined Infantile Alexander’s Disorder- pathology demyelinating leukoencephalopathy- a hereditary disease which expresses itself in the early childhood.

For Alexander disorder, its mutation in glial cells known as astrocytes promotes the growth of the myelin sheath by inhibiting the cell type precursor. The myelin sheath protects the nerves and fosters the nerve impulse transmission in the brain.

In astrocytes, dwells a gene called ApoE4, responsible to prompt the growth of Alzheimer’s disease and other neurological disorders. The only way to suppress the mechanism of Alzheimer’s and Parkinson’s is to maintain the operation techniques of astrocytes in Alexander, and hence the cure of Alexander along with Alzheimer’s and Parkinson’s is possible.

It was to find how gene mutations called GFAP in astrocytes suppress the action of the myelin sheath. To find this, GFAP mutation was collected from a patient’s brain.
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• Glioma Stem Cells Prevent The Effects Of Surgery and Chemotherapy

Further Observation Of The Study

Based on the gene mutation, a stem cell therapy model was built to identify the growth of Alexander disease and find ways to develop and evaluate therapeutic interventions for nerve related disorders. When the data of the patient with Alexander disease was observed, both the results hinted at protein deposits known as Rosenthal fibers.

With CRISPR/Cas9 gene editing techniques, the mutation of GFAP astrocytes was corrected. This helped reduce the mutations in GFAP of the patient’s brain, and also the protein deposits.

How to cure Disease Alexander

Further examination of the study found that stem cells of the patients with Alexander disease the mutation in astrocytes cause the secretion of protein CHI3L1 GFAP, suppressing the growth of myelinization and causes neuroinflammation.

Therefore, any therapeutic that inhibits the functions of CHI3L1, can help reduce the symptoms of Infantile Alexander and even cure it and other degenerative diseases like Alzheimer’s and Parkinson’s disease.

We can hope for the best to come up in the near future and cure our conditions of neurological disease so that we can lead a quality life in the society.

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