The regeneration of damaged tissues or organs has achieved an advanced feat since the advent of stem cell therapies. Not only do these magic cells result in the development of better cell-based therapies for many chronic illnesses, they have created a new benchmark in cosmetic technology for physical modifications too. For the successful cell-based therapies with regard to cosmetology, the whole process takes long days of research and hard work to confirm their efficacies. In addition, the effectiveness of any new product must go through some clinical trials so as to establish their usefulness to the users and validate their safety for use.

So, when an extreme hair loss raises your concerns about your look and your stance in the perspective of the social spectrum, you lose your heart. If you are really careful and want a solution to this issue, stem cell therapy can find you a way out.

Although you are not alone whose life is affected by this gruesome physical flare-up, about 40 million men and 21 million women are facing extreme hair loss problems in the United States. For the perfect solutions, they do really need an immediate hair regeneration therapy involving stem cells as all the current available hair growth options prove ineffective. An average of 7% of affected people do not show any interests to find any treatment for this, or their general reluctance prevents them from choosing a hair transplant surgery. Therefore, the scenario to improve the hair loss problems is not so promising for many due to these reasons.

Nonetheless, women can at least find a way out of their problem, and they do not need to go for any hair transplant procedure. A San Diego based regenerative medicine company- Histogen has received an approval from the Food and Drug Administration (FDA) to apply for the Investigational New Drug (IND) for the clinical trial. This process is paving the way for them to carry out a study on their proposed female regenerative product.
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• Stem Cell Therapy For Hair Loss Treatment And Cure Baldness

The company is aiming at introducing a component to this female product known as Hair Stimulating Complex (HSC660). The product is an injectable substance, which can work after its application onto the scalp. Since the company is associated with tissue or organ engineering with their products, this new hair product also aims at stimulating the users’ stem cells to reengineer tissues or stimulate their hair follicles to trigger hair growth in women.

The component of the product is manufactured at their bioreactors using cell media condition to focus on their growth factors. HSC 660 compound contains different growth factors, including follistatin, keratinocyte growth factor (KGF) and vascular endothelial growth factor (VEGF). Follistatin triggers the division of hair follicle stem cells, while the two other growth factors foster hair growth as well as stimulate dormant hair follicles.

The formulation of the product contains complex biological ingredients enriched with naturally secreted growth factors and proves to be effective as well for alopecia- an autoimmune condition causing hair loss in patches.
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• Regrow Hair With The Boon Of Stem Cell

As the product has shown its efficacy in their bioreactors, now they are approaching to go on a clinical trial on women with HSC660.

In addition to the promising aspects of the product, another recent study showed to be effective to solve difficult-to-treat hair conditions like temporal recession hair loss in younger populations of 40-plus years old both men and women.

With a green signal from the FDA, there is a possibility for us to stave off this problem soon and trigger new hair growth.

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When hair fall starts setting in, most of the people experience the same phenomenon, which reminds them of their full head of super and bouncy mane in their teens. However, with age, the same features of the full head do not remain the same, and you are supposed to see your hair washing away in the shower drain, on the hairbrush, with fewer numbers of strands remaining on your head.

It is the rule of the nature that furry mammals are bound to lose their hair with age, and their thick coat of hair will soon thin out.

None of us has an insight into the poor performances of the aging follicles other than the scientists.  But, what is baffling about the whole thing is that how hair follicles fail to function properly to accelerate the hair growth with age.

Japanese scientists have cleared the pathway. They found the factors hindering hair follicles from performing at a greater length with age.  As with other stem cells of living organisms, hair stem cells foster a rejuvenation of hair growth from the roots. But, it is because of aging, hair stem cells become weak and start falling. The study carried out at the Tokyo Medical and Dental University, focused that a massive chemical change to the DNA of these hair follicles due to wear and tear causes stem cells of the hair to prevent new hair growth. In fact, with times the reaction of wear and tear pushes the follicles to become smaller in sizes and hinders new hair from growing.

Since hair follicles shrink over time due to chemical reactions of hair DNA, hair follicle stem cells cannot advocate for new hair growth. The scientists found the factors triggering this chemical process and became successful to find a way to curb the performance of aging follicles too.

While this research is raising hopes to reverse the aging process of hair follicle stem cells, another study by the University of California discovered a new way to generate bright hopes for us too. They have found a new way, which is supposed to activate the hair follicle stem cells to trigger a new hair growth. The finding is useful for individuals having hair loss problems due to stress, alopecia, hormonal imbalance, chemotherapy reactions and aging.

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The hair follicles remain in their ‘quiescent’ state, meaning they remain inactivated until a new hair cycle follow. This prompts for a new hair growth. When the quiescence of hair follicles is influenced by a range of factors, it causes hair loss.

Every cellular metabolism is important for energy production and cell proliferation. Hair follicles require nutrients for metabolism and produce a metabolite called pyruvate. This metabolite turns into lactate when coming in contact with mitochondria. Studies show that when the function of lactate in mice is blocked, they don’t prompt for any hair growth. And when the lactate production is increased, it fosters new hair growth and one the other hand hair follicle stem cells on being activated renew the hair cycle.

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The application of drugs RCGD423 helps cellular signaling pathway JAK-Stat to accelerate the production of lactate. As a result, it promotes hair follicle stem cell activation and hair growth later. Another drug, UK5099 executes the same functions to increase the lactate production and aid in hair growth in mice.

We are looking forward to the clinical trials of these studies on humans so as to they can be authorized for use on humans at the earliest.