August 2018 - Stem Cell Therapy Treatments

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August 24, 2018

Stem Cell Therapy-Regeneration Of Neural Stem Cells For Spinal Cord Injuries

August 24, 2018 0

Stem Cell Therapy-Stem Cells Derived Neurons May Cure Spinal Cord Injuries

Stem Cell Therapy For Spinal Cord Injury: Over the past few years, stem cells have evolved as a promising therapeutic source, traversing those previous concepts of inability to treat irreparable neural injuries.stem cell therapy for spinal cord, spinal cord injury treatment with stem cell therapy.

The anecdotes of medical history are an example of why modern medicines were not able to treat the issues of spinal cord injuries, leaving thousands of patients paralyzed and causing them the loss of functional abilities.stem cell therapy for spinal cord, spinal cord injury treatment with stem cell therapy

Why Spinal Cord Injuries Still Untreatable With The Modern Medicinal Therapy?

There are various reasons that contribute to the paralysis of these patients and influence the restoration of their physical movement and independent physical control. One of the key reasons why spinal cord injury cannot be treated as no catalysts work properly to cultivate new neurons, responsible to develop and strengthen the spinal cord. embryonic stem cell treatment therapy for spinal cord injury, stem cell therapy for spinal disorder.
treating spinal cord injuries
Besides that, regenerating new tissues for the damaged spine requires a donor to implant the newly developed tissue, which is not feasible for many for being a costly surgical affair. Other than this, the regenerative stem cell therapy for the new spinal tissue development did not see much success. Hence, foraying into this venture for the researchers is quite risky.

However, stem cell-based therapy seems quite promising for spinal cord injuries at this point of time.

In order to activate the motor functions, it requires addressing the regeneration of the corticospinal tract (CST) in the rodents. CST is an important region of the spine that develops the communication process with the brain. Upon failing to establish a communication with the brain, it leads to loss of motor functions. Well, this is an important aspect of treating spinal cord injury, which is still infeasible for many researchers. stem cell therapy for spinal cord treatment, stem cell for spine injuries,
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However, researchers have claimed to reverse the negative effect of the spinal cord injury that inhibits the growth of new neurons.  They have discovered a new method of inducing ‘generic’ human stem cells that can differentiate into stem cells more specific to the spinal structure.

New Technique Of Cell-Based Therapy For Spinal Cord Injury 

Earlier, multipotent cells, a kind of progenitor cell-based CST graft trials were in use to address spinal cord injury. For not being true stem cells, the strategy did not yield potential results.

However, these days, human embryonic stem cells or induced pluripotent stem cells are used as a key source for this health complication. These cells are reprogrammed to regenerate CST, and also other needed spinal cord tissues required to replace the damaged spinal tissues in the spinal cord.
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At the same time, the study focused that these neural stem cells are more capable of developing different types of neurons via differentiation process. Although this finding works in a certain eligible model, it raises hopes that stem cell-based neurons are capable of growing damaged or missing spinal cord tissues.
In the study, the researchers influenced stem cells to regenerate ‘customized spinal graft’ for transplantation in the subjects.

How The Researchers Proved The Effectiveness Of The Study?

The CST based grafts were well integrated with pre-existing spinal tissues, consisting of various inputs related to neural connections specific to the location. This reprogramming of the neural system aimed at influencing peripheral functions like movement under normal conditions. However, it was only possible if the grafts were able to make a differentiation between the dorsal and ventral parts of the spine, responsible to send communication signals to the brains in an average healthy spine.

The study was successful to establish the capability of the grafts to facilitate this behavior in the models, and restore their motor skills.

This new discovery is awaiting the approval to be used in the real world treatment.

Since it is a successful discovery of the regeneration of neural stem cells for spinal cord injuries; we can look forward to use the same technique to be used for other spinal disorders too.


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August 21, 2018

Stem Cell Therapy Offers Treatment Options For Cartilage-Hair Hypoplasia

August 21, 2018 1

Stem Cell Therapy Transplant Offers Successful Treatment Options For Cartilage-Hair Hypoplasia

Stem cells are not a host of news that most people are eager to know about it. But, there are still a few clinical approved pieces of research that have been showing some great efficacies regarding the clinical uses of stem cell research. There are many pending clinical applications of the stem cells for a wide range of conditions, including cancers, which are under the process of the clinical trials. stem cell therapy for hair hypoplasia, stem cell transplant for hair hypoplasia.

However, so far whatever has been approved for stem cells in clinical trials, they have been proved the potential to treat and offer effective results to genetic syndromes with evidence of immune deficiency. As with many such immune deficiencies, stem cell transplants prove to be beneficial in treating cartilage-hair hypoplasia or (CHH), also referred to as metaphyseal chondrodysplasia. The transplantation aims at improving health conditions victimized by the blood stem cell or immune system related health conditions like cancers and many degenerative diseases. The treatment procedures cure the ailment by restoring the blood systems of immunodeficiency diseases. hair hypoplasia treatment with stem cell therapy, stem cell therapy for cartilage-hair hypoplasia.

Provided cartilage-hair hypoplasia or metaphyseal chondrodysplasia, stem cells offer the best treatment opportunities while improving the health conditions and also the quality of the life of the sufferers.
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Cartilage- Hair Hypoplasia And Its Effects On Life
Cartilage-Hair-Hypoplasia

Cartilage- Hair Hypoplasia or CHH is an autosomal recessive disease, and also a type of bony dysplasia characterized by a little to no hair with short fingernails, short dwarfism physical stature due to immunodeficiency along with different immune defects, including a varied degree of combined humoral immunodeficiency. stem cell therapy for bone marrow transplant,

It means this inherited disease results in bone deformities including a weak and beak immune system. An average of 15% of the population that suffers from this rare genetic disease has some different characters such as fine, sparse hair, in which alopecia affects the hair growth largely and causes hair losses with no natural hair pigmentation.

Patients with CHH may have different symptoms that feature normal hair growth for some, while others feature normal immunology. However, the occurrence of this immunodeficiency disease emphasizes the immunological defects, which inhibits the cellular immune response, especially CD4 cells. A short of chromosome 9 causes a gene mutation, leading to the occurrence of this disease. People with CHH have 86% grip of the immunodeficiency, which later may attract the harsh outcomes as a result of severe combined immunodeficiency, increasing the vulnerability of life-threatening infections.
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Primary Symptoms Of CHH

In general, CHH has a wide range of symptoms, including
• Bony structural abnormalities including spinal cord defects
• Inadequate while blood cells
• Short limbs and
• Anemia
Referred to as an inherited autosomal recessive, this rare hereditary disease is generally passed through both the parents, yet none of the parents show any signs of the disease.

    Complications Of CHH

    • Autoimmune ailments
    • Infection vulnerability
    • Immune system cancer, such as lymphoma
    • Blood cancer, such as leukemia
    • Gastrointestinal complications and
    • Skin cancer

    Various Treatment Options For Cartilage-Hair Hypoplasia

    Patients suffering from CHH with related immunodeficiency complications can get treatment choices like vaccinations and immunoglobulin replacement therapy, and antibiotics for infections.
    For more severe conditions like the severe combined immunodeficiency, the stem cell therapy transplant using hematopoietic stem cells can offer a potential and effective result. Sometimes, the treatment procedure involves bone marrow transplant and blood transfusion.

    Outcome Of Hematopoietic Stem Cell Transplant

    A previous survey by the European Bone Marrow Transplant group in 2010, reported a successful stem cell transplant for 16 CHH patients. The transplant was successful as it improved the life expectancy of the 63% of the participated patients, making them the long-term survivors for around seven years.
    At the same time, the survival rate of the patients has been increased by 80% using HLA matched donor stem cells. It is to note that HLA matched donors increase the success rate of the stem cell therapy transplant as compared to unrelated matched donors.
    Since stem cell transplant is a hope against the immunodeficiency disease like Cartilage- Hair Hypoplasia, we need more advanced research for stem cell to be available for every patient at an ease.

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    August 17, 2018

    Check Out How Anti-Aging Stem Cell Therapy Help With Frailty

    August 17, 2018 0

    Anti-Aging Stem Cell Therapy Could Help With Frailty

    Every living organism is made up of stem cells, and they are great elements that hold the secrets to staying disease free of various chronic ailments and even staying young. This is what scientists claim for stem cells that they are the only way to everlasting health and wellness.
    So, while talking about doing away with frailty, it is highly dependent on stem cells as per the researchers. Yes, aging can be inhibited, so can be its effects on health using the stem cell therapy or tissue engineering therapy.
    In recent two human trials, the results showed some promising avenues regarding anti-aging stem cell therapy that reverses the effects of age-related frailties and other conditions. And much to your surprise, the consequences of the stem cell trials on humans are absolutely safe and effective.
    Anti-Aging Stem Cell Therapy

    How Anti-Aging Treatment Breathes Its Life Through Research?

    There have been many examples of how stem cells have been saving many well-known faces from their woes as well as transforming them cosmetically. We have the likes of Kim Kardashian, David Beckham, and Simon Cowell to opt for stem cell therapy to hold onto their youthful appearances for long. This is completely a cosmetic purpose to look beautiful and flawless forever. This apart, many popular sports personalities like Diego Costa, Angel de Maria, Kobe Bryant and even Tiger Woods chose stem cell therapy to get rid of their injuries, yet they are rumors. Well, it is the magic of stem cell therapy that has restored their sports career on a perfect track, or else we would have seen an end to their great forms in no time.

    Hence, we can be sure of the efficacy of the anti-aging stem cell therapy treatments.
    Studies also threw light on some recent successful developments of stem cells targeting the anti-aging factors.
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    A discovery of protein in older mice reinstates the aging process by suppressing the graying of hair and also enhancing their physical fitness. Another study proves that using fecal transplant; it is possible to increase the lifespan of some fish. Hence, all these hints at how potentials are stem cell therapies to restore aging and reverse its effects.

    Key Stem Cells To Trigger This Anti-Aging Benefits In Humans

    Mesenchymal stem cells are a type of adult stem cells. These cells are great elements to be a huge target for scientists for disease modeling. These cells are a center of attraction as their disease-fighting capabilities are high against more than eighty chronic pathological conditions from cancer to cardiovascular diseases.
    Now, this cell type is a target in the human trials to assess its anti-aging strength so as to defy the effects of frailties on adult populations. And now, the trial is awaiting a nod from the FDA to clear the final stage of approval.
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    The whole research has been detailed in a guest editorial in The Journal of Gerontology.

    How The Therapy Works To Restore Aging?

    As we age, our muscles tend to lose its elasticity as well as regeneration capabilities. Hence, we are likely to fall ill and become vulnerable to different diseases. It is stem cell therapy that suppresses the aging effects.
    Stem cells are cultured in the lab under controlled conditions. They are then injected into the damaged area to replace those cells. The cells go to the damaged site and adjust to the area, while the local cells release ‘distress signal’. The cells proliferate and mature into cells just like the specific cells of the site and regenerate new tissues and organs. The stem cell therapy is powerful to replenish the damaged cells by proliferation and make one look youthful and rejuvenated.
    It is not only anti-aging treatment that gives us a relief from frailty, but also from a wide range of debilitating ailments at an affordable rate. So, let us hope that the stem cell therapy could bring advanced healthcare for all very soon. 

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    August 15, 2018

    Stem Cell Therapy To Repair Human Joint Injuries With Crocodile Cartilage

    August 15, 2018 0

    Stem Cell Therapy To Repair Human Joint Injuries With Crocodile Cartilage

    Joint pain, mostly due to arthritis is the leading cause of worldwide disability, leaving twice as many as people bedridden for their entire life. With no possible cure in sight so far, the treatment possibilities of arthritis and its various types now can see the lights at the end of the tunnel because of the stem cell therapy. Earlier stem cells have been proved to be a boon for a varied chronic and debilitating diseases like that of leukemia, neurodegenerative disease, Parkinson’s disease, dementia and multiple sclerosis and not to mention the problems related to the eyes.
    Treating joint injuries along with different forms of arthritis is now even easier with 3D printing in combination with stem cell therapy and crocodile cartilage. Doesn’t it sound so weird? Perhaps yes, it is not impossible though.
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    Arthritis And Its Treatment Procedure
    stem cells for knee injuries

    Arthritis needs a closer detection of the injury to identify its pathophysiology through arthroscopic surgery. The process of the surgery enables the identification of the injury in the cartilage, facilitating the treatment of joint injuries using the arthroscope. Arthroscope involves a small device, which needs to be inserted into the injured joint through a small incision. Although it is a non-invasive joint surgery, it does yield painful results for the victims as the recovery period is quite lengthy.

    However, this little painful consequence is envisioned to be overcome using the 3D printing technology in compliance with stem cell therapy and crocodile cartilage. This new treatment procedure will help in finding a therapeutic for joint injuries due to arthritis.
    The joint injuries and arthritis are highly prevalent among sports athletes, who cannot join the fields once they undergo the procedure of the arthroscope. Now, this process could be a passé and thanks to Dr. Pardraig Strappe for discovering a novel process to diagnose the ailment and treat without any minimal pain along with a faster recovery result.

    How The Processes Of 3D Printing Work?

    Dr. Strappe with his team of researchers from Center Queensland’ University is eyeing to activate the human immune response by using crocodile cartilage with its growth factors and turning off the proteins. The process actually turns adult stem cells into bio-print cartilage explants for the transplantation into the injured or damaged human joints. Hence, it is proof that crocodile cartilage could be a great resource to turn stem cells into human cartilage and cure joint injuries or arthritis.

    Since the crocodile cartilage turns human adult stem cells sourced from bone marrow or other cells into cartilage, they can alleviate the joint pain and distress in many, especially in adult populations. Along with the development of cartilage, it seems possible to promote cartilage repair too.
    After a knee injury, it is likely that the joint develops a crack or fissure in the knee or joints, which cannot heal on its own due to lack of the blood supply system in the cartilage. However, as cartilage develops a crack, it eventually becomes a hole, this needs a treatment.
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    So, by using a 3D printing, we can have an exact graph of the injury that mimics the hole in the 3D printing, making it clear for the surgeons to fill the gap easily.

    Why Crocodile Is The First Choice?

    The crocodile has a larger amount of growth promoting compounds like proteoglycan in the cartilage. And the compound is highly available near the rib cage. Hence, the resource for joint injuries or arthritis is immense. This is the first focused report conducted by the Commonwealth Scientific and Industrial Research Organization (CSRIO), which makes it possible for a crocodile to have varied movement procedure using their articulating joints. So, this cartilage is useful to turn stem cells into active cartilage and to be used as a human cartilage in the joints.
    Now, the focus will be on the availability of the procedure that will relieve the tensions of arthroscopic surgery in no time, and enable us to live a happy life without the fear of disability.

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    August 09, 2018

    Stem Cell Therapy Model To Treat Diseases Of The Nervous System

    August 09, 2018 0

    Stem Cell Model To Treat Diseases Of The Nervous System

    It wasn’t until the discovery of stem cell therapy that the treatment of neurodegenerative disease was believed to be an impossible event. Hence, any disease pertaining to the nervous system, including cancer, congenital disorders, and degenerative diseases such as Parkinson’s disease and Alzheimer’s disease and multiple sclerosis including traumatic diseases were among the incurable diseases. However, the tissue reparative and regeneration potentials of stem cells had removed the roadblocks to expanding the treatment scopes of replacement therapy for scientists.

    Stem Cell Therapy Disease Modeling

    Based on thousands of clinical studies and research works on stem cells and its disease treating potentials, the stem cell therapy transplantation proves to be life-saving for many chronic and life-threatening diseases like cancers, amyotrophic lateral sclerosis. Now, a new research has proved that monitoring the mechanisms of various nervous system diseases like Parkinson’s disease and Alzheimer’s disease is possible with the stem therapy cell model. Previously, this is what has been an unimaginable phenomenon for many.
    Now, treating any disease related to the nervous system is easier, since scientists for the first time have discovered a novel method to monitor the disease using stem cells.
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    This disease modeling is helpful in determining the etiologies of the diseases and find treatment options for varied neurodegenerative diseases like Parkinson’s, Alzheimer’s and sclerosis. A team of scientists at City of Hope National Medical Center has discovered a model of stem cells to evaluate the disease types of the nervous system. This disease model is helpful in suppressing the actions of Alzheimer’s disease, including various neurodegenerative diseases.

    In order to find the efficacy of the disease modeling, the scientists monitored Alexander disease- a similar kind of a nervous system disorder like that of Alzheimer’s.

    Stem Cell Therapy Model To Detect The Mechanism Of Neurodegenerative Disease

    In order to identify how neurological disease works and hinders one’s mental strength, they examined Infantile Alexander’s Disorder- pathology demyelinating leukoencephalopathy- a hereditary disease which expresses itself in the early childhood.
    For Alexander disorder, its mutation in glial cells known as astrocytes promotes the growth of the myelin sheath by inhibiting the cell type precursor. The myelin sheath protects the nerves and fosters the nerve impulse transmission in the brain.

    In astrocytes, dwells a gene called ApoE4, responsible to prompt the growth of Alzheimer’s disease and other neurological disorders. The only way to suppress the mechanism of Alzheimer’s and Parkinson’s is to maintain the operation techniques of astrocytes in Alexander, and hence the cure of Alexander along with Alzheimer’s and Parkinson’s is possible.
    It was to find how gene mutations called GFAP in astrocytes suppress the action of the myelin sheath. To find this, GFAP mutation was collected from a patient’s brain.
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    Further Observation Of The Study

    Based on the gene mutation, a stem cell therapy model was built to identify the growth of Alexander disease and find ways to develop and evaluate therapeutic interventions for nerve related disorders. When the data of the patient with Alexander disease was observed, both the results hinted at protein deposits known as Rosenthal fibers.
    With CRISPR/Cas9 gene editing techniques, the mutation of GFAP astrocytes was corrected. This helped reduce the mutations in GFAP of the patient’s brain, and also the protein deposits.

    How to cure Disease Alexander

    Further examination of the study found that stem cells of the patients with Alexander disease the mutation in astrocytes cause the secretion of protein CHI3L1 GFAP, suppressing the growth of myelinization and causes neuroinflammation.
    Therefore, any therapeutic that inhibits the functions of CHI3L1, can help reduce the symptoms of Infantile Alexander and even cure it and other degenerative diseases like Alzheimer’s and Parkinson’s disease.
    We can hope for the best to come up in the near future and cure our conditions of neurological disease so that we can lead a quality life in the society.

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    I am an avid health Blog writer. I write for several health sites and blogs, do thorough research work and accumulates all essential information that makes the blogs informative and enhances their value.