Stem Cell Therapy Treatments: Heart Transplant

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Showing posts with label Heart Transplant. Show all posts
Showing posts with label Heart Transplant. Show all posts

July 05, 2018

Stem Cell Therapy Lending Its Hand To Cure Heart Impairment

July 05, 2018 1

Stem Cell Therapy Lending Its Hand To Cure Heart Impairment

Stem cell therapies have been doing the rounds since long because of their life-saving potentials and best medical applications for chronic diseases and also disease testing. As with many other health complications, cell-based therapies are showing satisfactory results for heart disease also. According to a study published by the American College of Cardiology’s 65th Annual Scientific Session, a novel stem cell therapy can improve long-term health complications associated with severe and final stage cardiac disorder.

Cardiac Complications

So, what does happen when your left ventricle of the heart start malfunctioning? It stops pumping blood to your body, preventing all the necessary physical functions at its best. Gradually, it contributes to many complications, which later weakens your cardiac functions.  Sometimes, the condition increases the chances of sudden cardiac death due to loss of cardiac functions. This is one of the natural reasons for most adults in the U.S to lose their lives. We cannot refer to sudden cardiac death as heart failure, but it is a condition, occurring during the heart attack or failure. However, stem cell-based therapies or therapeutics can facilitate the cardiac treatment and enhance the living and quality of life of the victims at ease.
cardiac function
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While the therapeutics offer multiple clinical benefits for the cardiac patients, they are promising as well to heal wounds in the cardiac system. Maybe, this is surprising for you, but it has happened recently, which claims to heal the 11-year-old boys wound in the left ventricle and resurrects him to get back to his normal life with a little ability to perform tasks.

How Stem Cell Helped The Boy To Lead A Normal Life?

It has been all because of the stem cell procedures, which enabled Braden Heckendorn to fight tough battles with his life over the past few years and lead an active life today.
In December 2013, Braden Heckendorn was playing with a pellet gun in his relative’s house. Meanwhile, the gun malfunctioned and the pellet shot through his armpit and finally hit his left ventricle. He was down with no sense for twenty minutes, while his father, Bruce Heckhendorn was doing cardiopulmonary resuscitation on him. This helped him revive but he suffered a major heart stroke after 96 hours. He was admitted to the hospital with a range of health issues like sight difficulties, inability to talk and walk. Since he had developed brain injuries; the doctors had limited options to provide better clinical benefits to him. When all the methods failed, Braden’s parents turned to a stem cell institution to collect a match for their child and approached them to develop tissues for him. Braden Hackendorn gave his blood sample to one of the stem cell organizations, which was manipulated later to turn into mesenchymal stem cells in a petri dish in a lab.

Coaxing stem cells to turn them into cardiac cells would have not possible five years ago in the U.S. And in the near future, it seems nearly impossible as the FDA has approved only cord blood-derived stem cells to be used for the clinical applications and drug development.
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However, he received the treatment for his injured heart from a stem cell organization in Mexico.
With his heart not functioning properly for 22 minutes after that accident, he became paralyzed.  But, after the transplant, he is perfectly alright and showing signs of improvement. He can use his hands to eat and dress himself.

Since mesenchymal stem cell therapy has been successful to cure his heart ailments; we can be hopeful to receive this type of therapy in abundance in the future too. And one day, there will be no more apprehension regarding chronic diseases and cancers too.

stem cell transplant, heart transplant, stem cell heart surgery, stem cell therapy for heart disease, stem cell research, congestive heart failure, heart attack symptoms, symptoms of heart disease
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June 28, 2018

Revival Of Heart Cells Using Stem Cell Therapy

June 28, 2018 0

Revival Of Heart Cells Using Stem Cell Therapy

In recent times, stem cell treatments have opened up a broad spectrum for many health conditions, especially for genetic disorders, immunodeficiency disorders, and spinal cord injuries and not to mention- the heart disease.
When we talk about the complications involved with cardiovascular disease, it makes sense to find out more about how stem cells are effective in the treatment of this disorder.

The Normal Heart Cells And Its Normal Function

Our heart is capable of renewing its cells from as early as our fetus stage. During this time, the heart grows by increasing their cells.  We can see a steady growth of heart cells as we grow up. There is generally no change and decrease in the total number of heart cells in a healthy and uninjured adult human heart.
Revival Of Heart Cells
According to the studies, the renewal capacity of heart cells has already been inherent in the heart from its fetus phase. This modest level of heart cell growth proliferates with the times but slows down when injured or goes under basal conditions.
In addition, our heart tends to grow its cells at every stage like adolescence, middle age and old age. Once reaching 50, we retain 55 percent of heart cells from our birth, while 45 percent of cells develop later in life.
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The growth of new heart cells following an injury

Do you believe the possibility of heart’s revival at a fast pace following an injury? In most cases, the rate of new cell growth to the injured heart is higher as compared to the heart remaining at a normal condition. It is not that you have to believe only those said words of some individuals. The statements have a validation of different research and studies, which focuses on its revival at steady speed after an injury. All this is possible due to the different therapies involving infusions, injections, and various cells derived implants like stem cell therapies. They prove beneficial for the injured hearts. The transplanted cells are effective in regenerating or renewing the injured heart cells in compliance with the existing heart cells. In addition, the new growth of heart cells in injured tissues in the cardiovascular structure is solely dependent on various sources of cells as well as their capacities.

Let us remove the veil from it and have it in a more clear way. As soon as the new heart cells are injected using bone marrow-derived stem cells, the retention remains at a low degree. However, the bone marrow-derived stem cells infused with CD43 proteins on their surfaces, become more effective for the renewal of new heart cells as their retention increases about tenfold. This protein takes a key role in migrating new stem cells into the heart muscles at a fast pace.

Disagreement about Stem Cells’ Effectiveness

Though the renewal of new heart cells or proliferation is possible with transfusions and stem cell transplant, the functional improvement of the newly transplanted stem cells into the heart is rarely achievable.  And hence, researchers are finding other ways to make the whole process of renewal of new heart cells workable for the patients. Therefore, they believe that the heart cells from early stem cells can be beneficial to regenerate new heart cells and contribute to blood pumping functions as well as the heartbeat in sync with the pre-existing heart muscle.

Successful Clinical Trials

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While there is a disagreement regarding the role of stem cell transplant in promoting an effective cardiac function, a large number of successful clinical trials can prove their usefulness. These trials can prove promising for us as they can bring the real and effective results of stem cell transplant to be used on humans from the lab setting with an approval.


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April 23, 2018

Stem Cells: Treating Heart Disease With Umbilical Cord Blood

April 23, 2018 2

Treating Heart Disease With Umbilical Cord Blood

So far, we have enough evidence that the stem cells derived from the umbilical cord blood have the potential to do the magic. The magic is nothing, but in the form of regenerative medicines and therapies, that could help us combat a range of chronic diseases. Now, the researchers at the American Heart Association has once again brought us good news for the patients with cardiovascular issues. The insight of their research has been published in the medical journal Circulation Research.


Until now, we have to use invasive procedures to cure the patients with heart failure complications. But, the latest findings focus to aid in the development of noninvasive therapies using the umbilical cord. By using the therapy, it will be possible to make improvements in the heart muscles and make changes to the quality of the life.

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The  Concern Over The Disorder
heart failure stem cells

When the heart muscle cannot have the ability to pump blood effectively, it is known as heart failure. Nearly 37 million people globally are suffering from this heart disease. We have too many medical advances, still, we cannot treat people with heart complications. And a huge number of patients die every year despite being diagnosed with heart failure symptoms. So, the finding of the study is useful for us to get rid of the disorder.

The Elaborate Finding Of The Research

The trial showed a huge potential in favor of the patients taking part in the clinical trials. As many as 30 patients with lower to moderate level of heart failure complications participate. They aged between 18 to 75. Before these patients could receive intravenous infusions of umbilical cord-derived stem cells, they all had minimal drug therapy. The donors for the trials had full-term developed placentas from which the umbilical cord has been derived. Some of the patients received placebo also to determine the efficacy of the stem cells.
stem cell heart transplant

Consequences Of The Stem Cell Therapy As Compared To The Placebo

  • The patients had an improved life with a flexible capacity to pump blood to the heart and back to the whole body.
  • The quality of life has been
  • There was no side-effect, which is a quite common post any stem cell transplants. This apart, no sign of alloantibodies, or what we know by immune complexes was not detected so far.
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Umbilical cord stem cells did not show any potential though, the current studies are quite promising. We could no longer worry about the adverse effects of the cardiovascular complications, from now onwards. As is with intravenous umbilical cord stem cells, they are easily available, and accessible. Therefore, they raise more positive hopes for us. They are free of all incumbrances as we generally find in case with embryonic stem cells. Since they do not cause any immune complexes, they are a great scientific tool for the scientists for medical advances.

Why Choosing Umbilical Cord In Place Of Drug Therapy?

Such discovery is a way of living life better for many patients with cardiovascular symptoms. Earlier we have many instances which showcase that drug-based therapy is ineffective in case of heart diseases. They are not able to offer maximum benefit to alleviate the heart failure conditions. And that’s being one of the leading causes of patients’ concer, they opt for different invasive therapies. There are heart transplantations and ventricular mechanical assist device therapies, which often prove to be quite pricey for the patients.  

“The finding of the study is quite promising for us, as they could pave the way to develop non-invasive and promising new therapy for the patients with cardiovascular complications,” said the study correspondent author Fernando Figueroa.

stem cell transplant, stem cell therapy for heart disease, stem cell research, stem cell therapy for cardiovascular disease, stem cell treatment for heart failure, stem cell heart regeneration
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April 12, 2018

Mesenchymal Stem Cell Therapy to Increase the Survival Rate in HLHS

April 12, 2018 0

Mesenchymal Stem Cell Therapy to Increase the Survival Rate in HLHS

Mesenchymal stem cell therapy seems an appropriate answer to the severities of HLHS disease. The congenital heart defects hypoplastic left heart syndrome (HLHS) does not allow babies to survive more than an average of five years after the birth. For the heart surgeons, it is one of the most challenging and complex forms of heart disorder to treat using surgeries and heart transplant.

Hypoplastic Left Heart Syndrome

The disorder leaves us with an incomplete developed left ventricle in the heart, which takes a key role in pumping blood to the lungs. As per the Centers for Disease Control and Prevention, every year 960 babies are exposed to this disorder, and if left untreated the outcome is always fatal.
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In normal, when we have healthy hearts, the right ventricle does not have to work hard to supply deoxygenated blood to the lungs from the body. The left ventricle, on the other hand, uses a greater level of strength to pump resupplied blood back to the body. However, with HLHS, the right side of the heart has to take the double workloads, as well as maintaining the blood circulation to both lungs and body. So, when the stress is too much for the right side of the heart, the heart fails to work and causes the baby to die.

Type of Treatments

HLHS requires three types of surgeries in order to be treated completely- the first one performed at the birth,  the second one at 4 months of age and the final one at the age of 2 or 4. However, it does not always promise to offer a curative treatment as patients with this disorder are more likely to die even after a heart transplant.
stem cell transplant for babies

Since open heart surgeries or transplant are not providing promising results, the only curative treatment option appears to be the stem cell therapy


We have more instances that support the use of stem cell therapy in the treatment of HLHS in babies. In a more recent incident, surgeons in Maryland injected the cells derived from bone marrow of the donor into the heart of baby Autumn Brown with HLHS. The four-month baby Autumn is now a part of the stem cell study with 10 babies at the  University of Maryland Medical Center. Both Wayne Brown and LeeAnn Janes, Autumn’s parents are hopeful for a better outcome of the clinical trial for their baby. As Autumn ’s mother wants nothing more than her healthy life, she expects that she will lead a normal life with implanted stem cells in her heart. More instances show that she is improving and will meet her relatives soon. Janes said, “I could see the stem cells as creating a super heart.”
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The Finding of Their Study

The research carried out by Dr. Kaushal had an objective of boosting or regenerating the right ventricle in patients with HLHS so that their right heart could pump blood strongly. Their research also showed that babies with implanted mesenchymal stem cells are doing well.
hlhs stem cell transplant babies

MSCs have allogenic properties, so they can easily expand in the culture, and are a perfect source for the trail. MSCs prove to be effective in restoring heart functions in a clinical trial, which focuses the same features for HLHS too. These cells are capable of forming heart muscles and restraining the heart muscle from dying.


The finding of the study suggested that the same techniques will work for patients with hypoplastic left heart syndrome too.

We have earlier seen that stem cells provide a great potential to regenerate heart muscles. So it is believed that the result of the study will work better in case of pediatric patients too. That’s because hearts in younger individuals have better opportunity to grow as opposed to the older patients since the body is still in the development phase.

So, we can hope this novel therapy will one day improve the health of little patients who have a vulnerability to mortality.

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March 18, 2018

Stem Cell To Offer A New Life To The Damaged Heart

March 18, 2018 0

Stem Cell To Offer A New Life To The Damaged Heart

Do you prefer investing to buy a new thing, if a little repair or patch could help you out? Definitely not! The process helps you revive the product’s life, and also saves you money from a big expenditure.This is how the same way a stem cell patch is aimed at healing the damaged or injured heart. And hence, they allow you to breathe a new life once again. The biologists at the University of Cambridge’s Stem Cell Institute developed such patches using the heart stem cells.

The Development Procedures Of Heart Patches

The team of researchers did not rely on the donor’s tissues. Instead, they collected stem cells from the heart tissues of the patients and developed live patches for the heart. The tiny patches are not very large in size, merely measuring about 2.5 square centimeters. However, it is a powerful tool to mend defects in the heart and can aid in recovering from a range of cardiovascular ailments.

heart transplant stem cells

In the lab, the heart tissues were cultured on a tray over a month. Researchers injected blood cells in those tiny heart patches and reprogrammed them. With the reprogramming inputs, the patch cells were capable of growing into different cells in the human body. For instance, they could regenerate various heart tissues, including epicardium, blood vessel cells, and heart muscle cells. Later a scaffolding tissue was used for the organization and alignment of the perfect heart tissues.

How The Heart Patch Will Work

The epicardium cells are an important compound in our body. They play a key role in the development of our cardiovascular tissues. That apart, when embryonic cells are going through a development process, epicardium tissues help in transferring signals to the developing heart.
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Since the heart patches are made from the heart tissues, they are easier to be adaptable to the damaged heart surface of the patient. These functional patches are adept at beating and contracting in sync with other cells in your body too.

How Can The Patch Be Assimilated To The Patients’ Scarred Organ?

The whole process of the assimilation of the heart patch takes less than a whole heart transplant. Surgeons are likely to do an MRI and ultrasound scan to trace the defect structure in the heart. This scar identification is necessary to develop a3D print of the customized heart patch. The surgeons stitch the stem cell patch to the scar of the heart. And the patch gets along well with the arteries and veins in the body.

The whole process seems to be useful for the patients with severe heart failure. In such case, the patient’s heart tries to adjust to the damaged tissues.

Benefits of the Stem Cell Patches

Until now, you have to wait for a matched donor for a heart transplant, and that too from a healthy and young people. But, it is not that young people die every day and hence the scarcity in the supply of the organ. Most often, patients die due to being on the waiting list for years.
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Another way, the techniques of injecting stem cells into the scarred heart, saw failures. The stem cells get lost in the bloodstream, and cannot stay closer to the damaged heart.

So, stem cell patch is a relief for you. The scaffolding tissues in the stem cell patch prevent the users from further use of immunosuppressant drugs. They also reduce the risk involved with heart transplants.

If the trials on animals get an approval, you can see a hasty process for the human clinical trials too within years.

stem cell heart transplant, stem cell therapy for heart, stem cell therapy for heart failure, stem cell therapy heart surgery, stem cell therapy heart repair, stem cells to repair heart damage
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I am an avid health Blog writer. I write for several health sites and blogs, do thorough research work and accumulates all essential information that makes the blogs informative and enhances their value.