Stem Cell Therapy Treatments: Stem Cells

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Showing posts with label Stem Cells. Show all posts
Showing posts with label Stem Cells. Show all posts

July 01, 2018

Muscle Stem Cells Could Help Old People With Work

July 01, 2018 0

Curbing Mutations In Muscle Stem Cells Could Help Old People With Work

Our ability to perform certain functions is dependent on how we exert the muscular techniques. As long as we are young enough, the muscular capabilities remain active and aid in the execution of different functions. But as we grow older, the muscular functions fall short of our expectations and cannot offer a greater level of strength to perform any tasks. This is something which occurs due to an unprecedented number of mutations in the stem cells of muscles. The mutations impair the regeneration of cells, and inhibit the further progress of muscle functions; as a result, it deprives older individuals of their physical ability to perform tasks. This new study has been brought to the light by researchers at Karolinska Institute.

The study has raised a hope to develop a new drug or medication to help build stronger muscles no matter how older we become.
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Reasons Behind Aging Muscles And Its Deformity

For everything which hinders our capacity to work properly while we age, is mainly for muscle stem cells or satellite cells. These cells do not exert any muscular functions as they remain dormant in the muscle tissues. However, they are likely to proliferate and specialize to replace damaged tissues or organs when influenced by the external forces like physical workout or injuries. This is a well-grounded restorative function of muscle stem cells, but these functions reduce too with age and it does not advocate for any tissue regeneration through self-renewal capacity. As a result, the agility and strength of aging muscles deteriorate and decline. Therefore, the study clearly focuses on how there is a distinct relation between aging muscle and stem cells.
stem cells of muscles
Until now, there has been no clear indication why aging muscles lose its flexibility to perform a task. But, this is now clear as the study has successfully established how mutations in muscles play a key role in hindering the task performing ability to age muscles as compared to their younger counterparts.

How The Study Validated Muscle Elasticity?

In the study, they found that a healthy 70-year-old could collect as high as 1000 mutations in each of their muscle cells. These mutations cannot inhabit every cell, and the cells without these mutations are better protected and providing an adequate performance capability to a person. The study was successful to focus that with age, this strength of the cells also declines for the natural cell division process. As a result, an aged muscle loses its capacity to repair DNA. This leads to a novel pathway for scientists to discover a new method to influence the muscle with a newly developed drug.

How The New Therapy Is Devised?

In order to invent a new drug to foster the DNA repair and inhibit the impairment of muscle elasticity and functions, scientists turned to single cell DNA sequencing methods. The single cell genome sequencing helped them identify how each muscle stem cell does have a direct influence from a complex mutational burden. At the same time, the number of these mutations is two-three times higher in the cells of aging persons than younger counterparts. This is the reason why younger individuals are more fit and active to perform their tasks with more flexibility and agility as they do not show any sign of higher number of mutations.

In addition to this, the new drug development would also take into consideration the role of physical exercise to counteract the mutational influence on the muscle cells.
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So, if researchers can find out a new trigger to reduce the influence of the mutational reactions in cells, it is possible to discover new workout programs for aging populations too. And we can expect healthy old people to lend their shoulders to increase the productivity of young individuals.

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April 12, 2018

Mesenchymal Stem Cell Therapy to Increase the Survival Rate in HLHS

April 12, 2018 0

Mesenchymal Stem Cell Therapy to Increase the Survival Rate in HLHS

Mesenchymal stem cell therapy seems an appropriate answer to the severities of HLHS disease. The congenital heart defects hypoplastic left heart syndrome (HLHS) does not allow babies to survive more than an average of five years after the birth. For the heart surgeons, it is one of the most challenging and complex forms of heart disorder to treat using surgeries and heart transplant.

Hypoplastic Left Heart Syndrome

The disorder leaves us with an incomplete developed left ventricle in the heart, which takes a key role in pumping blood to the lungs. As per the Centers for Disease Control and Prevention, every year 960 babies are exposed to this disorder, and if left untreated the outcome is always fatal.
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In normal, when we have healthy hearts, the right ventricle does not have to work hard to supply deoxygenated blood to the lungs from the body. The left ventricle, on the other hand, uses a greater level of strength to pump resupplied blood back to the body. However, with HLHS, the right side of the heart has to take the double workloads, as well as maintaining the blood circulation to both lungs and body. So, when the stress is too much for the right side of the heart, the heart fails to work and causes the baby to die.

Type of Treatments

HLHS requires three types of surgeries in order to be treated completely- the first one performed at the birth,  the second one at 4 months of age and the final one at the age of 2 or 4. However, it does not always promise to offer a curative treatment as patients with this disorder are more likely to die even after a heart transplant.
stem cell transplant for babies

Since open heart surgeries or transplant are not providing promising results, the only curative treatment option appears to be the stem cell therapy


We have more instances that support the use of stem cell therapy in the treatment of HLHS in babies. In a more recent incident, surgeons in Maryland injected the cells derived from bone marrow of the donor into the heart of baby Autumn Brown with HLHS. The four-month baby Autumn is now a part of the stem cell study with 10 babies at the  University of Maryland Medical Center. Both Wayne Brown and LeeAnn Janes, Autumn’s parents are hopeful for a better outcome of the clinical trial for their baby. As Autumn ’s mother wants nothing more than her healthy life, she expects that she will lead a normal life with implanted stem cells in her heart. More instances show that she is improving and will meet her relatives soon. Janes said, “I could see the stem cells as creating a super heart.”
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The Finding of Their Study

The research carried out by Dr. Kaushal had an objective of boosting or regenerating the right ventricle in patients with HLHS so that their right heart could pump blood strongly. Their research also showed that babies with implanted mesenchymal stem cells are doing well.
hlhs stem cell transplant babies

MSCs have allogenic properties, so they can easily expand in the culture, and are a perfect source for the trail. MSCs prove to be effective in restoring heart functions in a clinical trial, which focuses the same features for HLHS too. These cells are capable of forming heart muscles and restraining the heart muscle from dying.


The finding of the study suggested that the same techniques will work for patients with hypoplastic left heart syndrome too.

We have earlier seen that stem cells provide a great potential to regenerate heart muscles. So it is believed that the result of the study will work better in case of pediatric patients too. That’s because hearts in younger individuals have better opportunity to grow as opposed to the older patients since the body is still in the development phase.

So, we can hope this novel therapy will one day improve the health of little patients who have a vulnerability to mortality.

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March 17, 2018

Alzheimer’s and Dementia:Stem Cells To Reduce The Protein Functions In The Brain

March 17, 2018 0

Stem Cells To Reduce The Protein Functions In The Brain Of Alzheimer’s

The devastating neurological conditions may occur to people from severe blows to their heads. And finally, it takes the shape of mental illnesses like Alzheimer’s and Dementia. Dementia and Alzheimer’s patients need to be under constant treatment and medication to improve their conditions but to no avail.

Recent studies emphasize to improve the conditions of these mental illnesses of the patients. The curbing of the toxic build up in the brain using stem cell proteins may reduce the conditions. The Scientists at the University of Washington Health Sciences have thrown a light on it.

The Severity Of Alzheimer’s And Dementia

Around 5 million citizens of America are under the attack of this disorder. The occurrence of the disorder leads to memory loss, defects in the thinking process, and deterioration in the cognitive skills. It waves at other debilitating conditions as well.
Your condition may deteriorate with times, and it takes its peak with age. Why do you think what prompts this disease to take a toll on your mental stability?
Alzheimer’s and Dementia

Reasons For Dementia and Alzheimer’s 

Two chemical toxic deposits are responsible to cause you the mental illnesses. These two chemical compounds of proteins cause damage to the brain cells and destruction to them. The performance of the brain subsides as it loses cognition and reasoning techniques over the time.

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Two proteins amyloid beta and tau in the brain contribute to the development of the disorder. In the brain of the Alzheimer’s, these two compounds inhibit as a clump. The former one stays outside the brain compartment, while the latter accumulates in the brain cells. The toxicity of the two proteins causes death to the brain cells in the patients with Alzheimer’s. 
The membrane-bound packages known as endosomes take part in ferrying these proteins in the cells. The defects in these endosomes defer the movement of the cells, and as a result, the brain cells die.  Both the proteins are regulated by the endosomal network. The whole process and the functions of the chemicals depend on this network.

How Does the New Invention Creating Possibilities for Better Treatments? 

Human brain cells developed from the stem cells hold the way to the possible treatments. Any compound, drug or any therapy such as gene therapy is apt to improve the functions of the endosomal connectivity properly. It is capable of targeting the defects in the endosomal network and further restricting their adverse effects to the brains caused by amyloid beta and tau protein. And hence, with a new therapy, it can avoid the defects of Alzheimer’s. 

The Study In Favor of the Stem Cells use in Alzheimer’s Treatment

Induced Pluripotent Stem Cells or iPSC have the potential to develop into many cells with the same genetic mutation features found in the human cells. To act this way, iPSC undergoes the reset techniques, followed by the reprogramming. The characteristics of the cells remain the same in the skin of the Alzheimer’s patients. So, the researchers collected both the skin cells from the patients and healthy people and turned them into iPSC.

These skin cells received a cultural process to develop into neurons with the identical genetic mutation capability as the patients. Theses lab-grown neurons develop the same amount of amyloid beta and tau proteins as the Alzheimer’s patients do  Hence, it has made easier for the researcher to count the volume of the proteins in the lab-grown neurons.
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Further, the research establishes that a compound called retromer is responsible for improving the functions of the protein assembly in the brain in animals. And with the compound of R33, the functions of the retromer see a surge. Retromer then curbs the excessive production of the amyloid beta and tau proteins in the brain.
Hence, using iPSC, a new therapeutic treatment will open many ways to treat the conditions of Alzheimer’s.

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March 07, 2018

Type 1 Diabetes:Regenerative Stem Cells To Regrow Beta Cells

March 07, 2018 1

Regenerative Stem Cell Therapy To Regrow Beta Cells For Type 1 Diabetes

Thousands of progenitor cells inhabit the human pancreas. And they can breathe new life into many glucose-responsive beta cells. A cultural process at the laboratory can aid in the whole process. The scientists at the Diabetes Research Institute are seeing some possibility in this new finding. The development of glucose-responsive beta cells using progenitor cells is useful in developing regenerative cell therapies. And the patients with type 1 diabetes can receive a permanent and biological cure for this type of regenerative stem cell therapies.
Type 1 Diabetes

Why Is Type 1 Diabetes A Concern?


Diabetes is one of the widespread and daunting glucose disorders. The prevalence of the glucose immune disorder is rapidly increasing around the world. This is a condition, which is undying as long as the patient survives. Its dominance is high amongst the children. Type 1 Diabetes means living with a regular administration of insulin, followed by long-term of health issues.

It is an autoimmune disorder, which occurs when there is a vast destruction of the pancreatic β cells.

This is how therapies and new treatment option advocates for the restoration of the remaining beta cells, and regulation of T cell autoimmunity.
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Treatments for Type 1 Diabetes


Patients diagnosed with Type 1 Diabetes have to rely on exogenous insulin. An extreme need for insulin becomes obvious when the immune system damages the insulin-producing cells of the pancreas.   However, when the condition deteriorates like glucose level rises above the normal, it seeks the intervention of medication rather than insulin.
diabetes insulin

Islet transplantation comes to the rescue of the patients during the situation. The surgery of islet transplantation is very popular, which needs the donor’s islet cells or the whole pancreas. It is able to regulate the blood glucose level, and no more insulin injections are required. But, there are scarcities of enough donor cells to treat the conditions for the patients with type 1 diabetes.

Stem Cell Transplant For The Cure Of Type 1 Diabetes


The islet transplant may cause many side effects and also lead to the failure of the transplant surgery.  Researchers have highlighted the other source of fruitful treatments. And it lies on the stem cell transplant. By developing more pancreatic cells from various sources like embryonic cells, pluripotent and adult stem cells, the curative treatment options are possible for type 1 diabetes. And the most effective options seem to lie in the regeneration of the insulin-producing cells from the patients themselves. Through regenerative therapy using the patient’s own pancreatic cells, it will eliminate the need of transplanting donor tissues. It will also be able to remove other hurdles from the treatment pathway.

How The Progenitor Cells Work To Develop Regenerative Therapy

Progenitor cells are capable of renewing islets in the pancreas. At the same time, they are proliferative, and hence they can turn them into beta-glucose cells. The ability to renew beta cells in the pancreas, it can lead to the development of the therapeutic treatment for the patients with type 1 diabetes.

The bone morphogenetic protein – 7 or (BMP-7) maintains the growth of the cells, and responsible for stimulating the progenitor-like cells. The cells in pancreas also respond to this protein. Other than this protein, PDX-1 and ALK3 involve in the development and regeneration of the beta cells. Therefore, it is possible to grow proliferative pancreatic cells in the presence of BMP-7 using ‘molecular fishing’ in the native pancreas. And with PDX 1 and ALK 3, they help them differentiate into beta cells.

With the regenerative medicine therapies, the native pancreas is able to restore insulin production. It eliminates the chances of transplant of insulin-producing cells and also the transplant of the pancreas.

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February 17, 2018

Stem Cells Raising Hopes For Improving Kidney Functions

February 17, 2018 0

Stem Cells Raising Hopes For Improving Kidney Functions

The stem cells’ capability of self-renewal and differentiation has made it easier for medical persons, and clinical professionals to bring about different treatment options for many inexorable ailments. And this time, the magic of stem cells is weaving hopes for the patients suffering from the kidney diseases.


In a major breakthrough, the scientists at the University of Manchester have developed a functioning mini kidney. They developed it using stem cells within a living organism. It is exciting for the patients suffering the renal disease. The mini kidneys are capable of producing urine and acting as similar to the human kidneys. This is a big milestone in the treatment of kidney diseases. And that's why they could aid in multiplying the future treatment scopes for the patients one day.
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Kidney Ailment- A Major Health Issue

A large number of populations is suffering from the kidney ailments. The mortality rate of the kidney patients is reaching an unprecedented number every year. Due to the chronic kidney failure, the kidney cannot produce urine. When the disease worsens, the kidneys fail to filter excess wastes and excrete fluids out of the body. As a result, at the advanced age, the wastes build up in the system and impair the kidney functions. The impaired kidneys impact the normal functioning of urine, and advocates for relief. To relieve this problem, patients have to undergo dialysis.
stem cells research

According to the study, around two million people opt for kidney transplantation or dialysis. But, most patients cannot afford these treatments.

The mini-kidneys developed with the stem cells are raising a silver lining for the patients with kidney dysfunctions.

The Development Process of The Mini Kidney or Kidney Tissues

The embryonic stem cells were the key elements to develop the kidney glomeruli in the living organism. Scientists fragmented these cells into different microscopic kidney tissues. And they used cultural dishes to grow them. The pieces were mixed with a gel-like substance that functioned as connective tissues. And the clump was then injected under the skin of mice. After three months, the functional tissues of the kidney- nephrons had developed.

The discovery has seen the wonders of the medical sciences for the first time. The kidney of the mouse or the nephrons included all the major parts as similar as the human nephrons. The experimental mice’s nephrons comprised distal tubules, proximal tubules, Bowman’s capsules, and Loop of Henle. To nurture the new formation of the kidneys, minute blood vessels found in the human body developed as well.


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Major Hurdle To The Success

The kidneys of human have a large artery to flow the blood to the kidney. But, the newly developed functioning mini-kidneys in mice miss this feature. This is a major hurdle to bring about the true medical benefits to the patients with kidney ailments.

A fluorescent protein called dextran is capable of straining urine from the blood during the glomerular filtration process. So, scientists used dextran in the mice to examine the functionality of filtration and excretion of urine.
stem cell therapy for kidney disease

When the scientists tracked dextran, they saw that it was able to filtrate urine and excrete it.

So, there is no doubt about the new structures’ capability of filtration and excretion like kidney cells. However, it is still unclear how effectively the new structures function in the living organism.


Still, it leads to a hope to create more advanced treatments using the pluripotent stem cells.

Future Hopes

Humans have innumerable glomeruli in their kidneys. And, this new structure has breathed a life through a few hundred glomeruli. Of course, they showed a sign of hopes for the future treatments in kidney ailments. And the further development and research using this technique may advance the existing treatment options for kidney diseases.


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I am an avid health Blog writer. I write for several health sites and blogs, do thorough research work and accumulates all essential information that makes the blogs informative and enhances their value.