Regenerative Stem Cell Therapy To Regrow Beta Cells For Type 1 Diabetes
Thousands of progenitor cells inhabit the human pancreas. And they can breathe new life into many glucose-responsive beta cells. A cultural process at the laboratory can aid in the whole process. The scientists at the Diabetes Research Institute are seeing some possibility in this new finding. The development of glucose-responsive beta cells using progenitor cells is useful in developing regenerative cell therapies. And the patients with type 1 diabetes can receive a permanent and biological cure for this type of regenerative stem cell therapies.
Why Is Type 1 Diabetes A Concern?
Diabetes is one of the widespread and daunting glucose disorders. The prevalence of the glucose immune disorder is rapidly increasing around the world. This is a condition, which is undying as long as the patient survives. Its dominance is high amongst the children. Type 1 Diabetes means living with a regular administration of insulin, followed by long-term of health issues.
It is an autoimmune disorder, which occurs when there is a vast destruction of the pancreatic β cells.
This is how therapies and new treatment option advocates for the restoration of the remaining beta cells, and regulation of T cell autoimmunity.
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Treatments for Type 1 Diabetes
Patients diagnosed with Type 1 Diabetes have to rely on exogenous insulin. An extreme need for insulin becomes obvious when the immune system damages the insulin-producing cells of the pancreas. However, when the condition deteriorates like glucose level rises above the normal, it seeks the intervention of medication rather than insulin.
Islet transplantation comes to the rescue of the patients during the situation. The surgery of islet transplantation is very popular, which needs the donor’s islet cells or the whole pancreas. It is able to regulate the blood glucose level, and no more insulin injections are required. But, there are scarcities of enough donor cells to treat the conditions for the patients with type 1 diabetes.
Stem Cell Transplant For The Cure Of Type 1 Diabetes
The islet transplant may cause many side effects and also lead to the failure of the transplant surgery. Researchers have highlighted the other source of fruitful treatments. And it lies on the stem cell transplant. By developing more pancreatic cells from various sources like embryonic cells, pluripotent and adult stem cells, the curative treatment options are possible for type 1 diabetes. And the most effective options seem to lie in the regeneration of the insulin-producing cells from the patients themselves. Through regenerative therapy using the patient’s own pancreatic cells, it will eliminate the need of transplanting donor tissues. It will also be able to remove other hurdles from the treatment pathway.
How The Progenitor Cells Work To Develop Regenerative Therapy
Progenitor cells are capable of renewing islets in the pancreas. At the same time, they are proliferative, and hence they can turn them into beta-glucose cells. The ability to renew beta cells in the pancreas, it can lead to the development of the therapeutic treatment for the patients with type 1 diabetes.
The bone morphogenetic protein – 7 or (BMP-7) maintains the growth of the cells, and responsible for stimulating the progenitor-like cells. The cells in pancreas also respond to this protein. Other than this protein, PDX-1 and ALK3 involve in the development and regeneration of the beta cells. Therefore, it is possible to grow proliferative pancreatic cells in the presence of BMP-7 using ‘molecular fishing’ in the native pancreas. And with PDX 1 and ALK 3, they help them differentiate into beta cells.
With the regenerative medicine therapies, the native pancreas is able to restore insulin production. It eliminates the chances of transplant of insulin-producing cells and also the transplant of the pancreas.
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Stem cells therapy is very useful for many diseases your information is very useful for many people because millions of people suffering from type 1
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