Stem Cell Transplant:Treating Bare Lymphocyte Syndrome

Treating The Conditions Of Bare Lymphocyte Syndrome With Stem Cell Transplant

Bare Lymphocyte Syndrome or most popularly known as MHC Class II deficiency is a rare form of immunodeficiency disease. Children are at high risk as the disorder leaves its impact mostly on them. The disease may attack the patients when there is either deficiency of HLA Class I or Class II antigens on the cell surface.The allogeneic stem cell transplant is the only curative treatment options for this immunodeficiency disorder.

Health Complications Of The MHC Class II Or BLS

The occurrence of the disease may defer your body from developing responsible genes through chromosome 6. It hinders antibody from forming and restricts the cells from responding to the specific antigens. It is evident to experience more physical complications in the respiratory and digestive tract. And as a result, your normal life finds it difficulty in breathing and digesting food.
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More severe complications are there for you when you develop the immunodeficiency disease. You are likely to develop hypogammaglobulinemia, which results in recurrent viral infections caused by parasites and bacteria.

Treatment Choices for BLS

You could find a treatment solution for this disease from allogeneic or HLA matched stem cell transplant. However, the survival rate of the patients is highly dependent on the donor cell types.  HLA matched donor transplant improves the survival quality, while the unmatched donor cell transplants offer you 50% of survival success.

Hindrances to SCT for BLS

The relief from the debilitating complications of the disease finds its way through a successful allogeneic stem cell transplant. On failure of the transplant, most children may succumb to infections in their first phase of life.
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Other than this, the alternative donor transplant does not suit the process of the Stem cell transplant. Similarly, other types of immunodeficiency diseases do not benefit from this process as well. Till date, the stem cell transplant using alternative donors increases the chances of Graft-versus-host-disease reactions, incessant graft rejections, and even mortality due to infections.

Study Favoring The SCT For Curing Bare Lymphocyte Syndrome

If you look at the finding of a study carried out on the 16 diseased children, you will have a clear idea about the efficacy of the SCT.

In 1990, 16 affected children were ready for the transplant with the samples. The specimens were derived from HLA unrelated family member, HLA matched adult donor and mismatched cord blood donor. These patients were under treatment in four different medical centers.
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None of the patients had experienced chronic GVHD after the first transplant. However, five patients who underwent the second phase of transplant experienced graft failure. And six patients amongst them developed acute GVHD complications. In spite of that, Stem cell transplant seems to offer the best survival results at 69% of success rate for the children.

Another process for the treatment of bare lymphocyte syndrome is utero stem cell transplant. Many fetal disorders or immunodeficiency disorders like BLS gain good benefits from the utero stem cell transplant.

Utero Stem Cell Transplant

The possible treatment for BLS depends on the maternal T-Cell to be injected intravascularly. With the use of the maternal cells, the results achieve the highest chimerism levels. The robustness of the transplant remains stable for a period of two years with no traces of GVHD. This apart, the utero stem cell transplantation offers many curative treatments for dreadful diseases.

This therapy also reduces the relapse complications caused due to GVHD. Simultaneously, the donor cells receive a better environment to develop in the host fetal cells.

So, we can expect more of such therapies to relieve the health compilations of BLS at the earliest soon after the transplant takes its course.

stem cell therapy, bare lymphocyte syndrome treatment, stem cells, stem cell research, utero transplantation of stem cells