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June 29, 2018

Stem Cell Therapy To Prevent The Dilemma Of Female Hair Loss Anxiety

June 29, 2018 1

Female Hair Product To Prevent The Dilemma Of Hair Loss Anxiety

The regeneration of damaged tissues or organs has achieved an advanced feat since the advent of stem cell therapies. Not only do these magic cells result in the development of better cell-based therapies for many chronic illnesses, they have created a new benchmark in cosmetic technology for physical modifications too. For the successful cell-based therapies with regard to cosmetology, the whole process takes long days of research and hard work to confirm their efficacies. In addition, the effectiveness of any new product must go through some clinical trials so as to establish their usefulness to the users and validate their safety for use.

Hair Loss And Its Effects

So, when an extreme hair loss raises your concerns about your look and your stance in the perspective of the social spectrum, you lose your heart. If you are really careful and want a solution to this issue, stem cell therapy can find you a way out.
stem cell female hair loss
Although you are not alone whose life is affected by this gruesome physical flare-up, about 40 million men and 21 million women are facing extreme hair loss problems in the United States. For the perfect solutions, they do really need an immediate hair regeneration therapy involving stem cells as all the current available hair growth options prove ineffective. An average of 7% of affected people do not show any interests to find any treatment for this, or their general reluctance prevents them from choosing a hair transplant surgery. Therefore, the scenario to improve the hair loss problems is not so promising for many due to these reasons.

Nonetheless, women can at least find a way out of their problem, and they do not need to go for any hair transplant procedure. A San Diego based regenerative medicine company- Histogen has received an approval from the Food and Drug Administration (FDA) to apply for the Investigational New Drug (IND) for the clinical trial. This process is paving the way for them to carry out a study on their proposed female regenerative product.
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Prospects of the Product

The company is aiming at introducing a component to this female product known as Hair Stimulating Complex (HSC660). The product is an injectable substance, which can work after its application onto the scalp. Since the company is associated with tissue or organ engineering with their products, this new hair product also aims at stimulating the users’ stem cells to reengineer tissues or stimulate their hair follicles to trigger hair growth in women.

Key Components Of The Formula

The component of the product is manufactured at their bioreactors using cell media condition to focus on their growth factors. HSC 660 compound contains different growth factors, including follistatin, keratinocyte growth factor (KGF) and vascular endothelial growth factor (VEGF). Follistatin triggers the division of hair follicle stem cells, while the two other growth factors foster hair growth as well as stimulate dormant hair follicles.

The formulation of the product contains complex biological ingredients enriched with naturally secreted growth factors and proves to be effective as well for alopecia- an autoimmune condition causing hair loss in patches.
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As the product has shown its efficacy in their bioreactors, now they are approaching to go on a clinical trial on women with HSC660.
In addition to the promising aspects of the product, another recent study showed to be effective to solve difficult-to-treat hair conditions like temporal recession hair loss in younger populations of 40-plus years old both men and women.
With a green signal from the FDA, there is a possibility for us to stave off this problem soon and trigger new hair growth.

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June 28, 2018

Revival Of Heart Cells Using Stem Cell Therapy

June 28, 2018 0

Revival Of Heart Cells Using Stem Cell Therapy

In recent times, stem cell treatments have opened up a broad spectrum for many health conditions, especially for genetic disorders, immunodeficiency disorders, and spinal cord injuries and not to mention- the heart disease.
When we talk about the complications involved with cardiovascular disease, it makes sense to find out more about how stem cells are effective in the treatment of this disorder.

The Normal Heart Cells And Its Normal Function

Our heart is capable of renewing its cells from as early as our fetus stage. During this time, the heart grows by increasing their cells.  We can see a steady growth of heart cells as we grow up. There is generally no change and decrease in the total number of heart cells in a healthy and uninjured adult human heart.
Revival Of Heart Cells
According to the studies, the renewal capacity of heart cells has already been inherent in the heart from its fetus phase. This modest level of heart cell growth proliferates with the times but slows down when injured or goes under basal conditions.
In addition, our heart tends to grow its cells at every stage like adolescence, middle age and old age. Once reaching 50, we retain 55 percent of heart cells from our birth, while 45 percent of cells develop later in life.
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The growth of new heart cells following an injury

Do you believe the possibility of heart’s revival at a fast pace following an injury? In most cases, the rate of new cell growth to the injured heart is higher as compared to the heart remaining at a normal condition. It is not that you have to believe only those said words of some individuals. The statements have a validation of different research and studies, which focuses on its revival at steady speed after an injury. All this is possible due to the different therapies involving infusions, injections, and various cells derived implants like stem cell therapies. They prove beneficial for the injured hearts. The transplanted cells are effective in regenerating or renewing the injured heart cells in compliance with the existing heart cells. In addition, the new growth of heart cells in injured tissues in the cardiovascular structure is solely dependent on various sources of cells as well as their capacities.

Let us remove the veil from it and have it in a more clear way. As soon as the new heart cells are injected using bone marrow-derived stem cells, the retention remains at a low degree. However, the bone marrow-derived stem cells infused with CD43 proteins on their surfaces, become more effective for the renewal of new heart cells as their retention increases about tenfold. This protein takes a key role in migrating new stem cells into the heart muscles at a fast pace.

Disagreement about Stem Cells’ Effectiveness

Though the renewal of new heart cells or proliferation is possible with transfusions and stem cell transplant, the functional improvement of the newly transplanted stem cells into the heart is rarely achievable.  And hence, researchers are finding other ways to make the whole process of renewal of new heart cells workable for the patients. Therefore, they believe that the heart cells from early stem cells can be beneficial to regenerate new heart cells and contribute to blood pumping functions as well as the heartbeat in sync with the pre-existing heart muscle.

Successful Clinical Trials

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While there is a disagreement regarding the role of stem cell transplant in promoting an effective cardiac function, a large number of successful clinical trials can prove their usefulness. These trials can prove promising for us as they can bring the real and effective results of stem cell transplant to be used on humans from the lab setting with an approval.


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May 10, 2018

Stem Cell Therapy For Hair Loss Treatment And Cure Baldness

May 10, 2018 1

Hair Loss Causes Hide In Hair Stem Cell Follicles

When hair fall starts setting in, most of the people experience the same phenomenon, which reminds them of their full head of super and bouncy mane in their teens. However, with age, the same features of the full head do not remain the same, and you are supposed to see your hair washing away in the shower drain, on the hairbrush, with fewer numbers of strands remaining on your head.


It is the rule of the nature that furry mammals are bound to lose their hair with age, and their thick coat of hair will soon thin out.

None of us has an insight into the poor performances of the aging follicles other than the scientists.  But, what is baffling about the whole thing is that how hair follicles fail to function properly to accelerate the hair growth with age.

Why Hair Follicle Does not Work? 

Japanese scientists have cleared the pathway. They found the factors hindering hair follicles from performing at a greater length with age.  As with other stem cells of living organisms, hair stem cells foster a rejuvenation of hair growth from the roots. But, it is because of aging, hair stem cells become weak and start falling. The study carried out at the Tokyo Medical and Dental University, focused that a massive chemical change to the DNA of these hair follicles due to wear and tear causes stem cells of the hair to prevent new hair growth. In fact, with times the reaction of wear and tear pushes the follicles to become smaller in sizes and hinders new hair from growing.
Stem Cell Therapy For Hair Loss

Since hair follicles shrink over time due to chemical reactions of hair DNA, hair follicle stem cells cannot advocate for new hair growth. The scientists found the factors triggering this chemical process and became successful to find a way to curb the performance of aging follicles too.


While this research is raising hopes to reverse the aging process of hair follicle stem cells, another study by the University of California discovered a new way to generate bright hopes for us too. They have found a new way, which is supposed to activate the hair follicle stem cells to trigger a new hair growth. The finding is useful for individuals having hair loss problems due to stress, alopecia, hormonal imbalance, chemotherapy reactions and aging.
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Amazing Fact About The Hair Follicles

The hair follicles remain in their ‘quiescent’ state, meaning they remain inactivated until a new hair cycle follow. This prompts for a new hair growth. When the quiescence of hair follicles is influenced by a range of factors, it causes hair loss.


Every cellular metabolism is important for energy production and cell proliferation. Hair follicles require nutrients for metabolism and produce a metabolite called pyruvate. This metabolite turns into lactate when coming in contact with mitochondria. Studies show that when the function of lactate in mice is blocked, they don’t prompt for any hair growth. And when the lactate production is increased, it fosters new hair growth and one the other hand hair follicle stem cells on being activated renew the hair cycle.
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How Drugs Facilitate The Hair Growth

The application of drugs RCGD423 helps cellular signaling pathway JAK-Stat to accelerate the production of lactate. As a result, it promotes hair follicle stem cell activation and hair growth later. Another drug, UK5099 executes the same functions to increase the lactate production and aid in hair growth in mice.

We are looking forward to the clinical trials of these studies on humans so as to they can be authorized for use on humans at the earliest.

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May 01, 2018

Stem Cell Therapy Reviving Hopes For Arthritis Patients By Producing Cartilage

May 01, 2018 0

Stem Cell Therapy Reviving Hopes For Arthritis Patients By Producing Cartilage

Adult stem cells have been in use for different biomedical researchers and novel therapeutic applications for a range of diseases since long. Once again, they prove to be a useful medical tool for debilitating conditions as Osteoarthritis. Since researchers have created balanced joint cartilage using adult stem cells, we can expect to get rid of the excruciating joint pain very soon with an effective transplant process. The researchers at the University and University Hospital of Basel created the liquid component known as cartilage applying certain molecular techniques. The process of the tissue development took place during embryonic cartilage formation. Every one of us could have an elaborate view on this report from the scientific journal of PNAS.
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What Osteoarthritis Is And How Does It Affect Us?
Stem Cell Therapy Arthritis

As we all know, osteoarthritis is a degenerative condition of the joints, which causes the destruction of the natural cartilage, weakening of bone density and inflammation. As per medical reports, maximum cases of osteoarthritis result in joint pain restricting the ability to perform normal activities, while affecting the normal quality of life. Until today, so many techniques and medical interventions have proved ineffective in healing the articular cartilage.
In addition to this, mesenchymal stem cell-based therapies have been showing promising hopes to advance cartilage repair. Despite some progressive advancement in the pre-clinical trials, these cell-based therapies are yet to get approval for use in clinical settings. Along with this, other new techniques are on the way to offer novel therapeutic uses for this condition. MSC-based extracellular compounds, improved CRISPR CAS 9 gene editing tools, and miRNAs are devised for the development of new strategies for OA.
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While these are under process, we have another new entrant as a form of stem cell-based cartilage to alleviate our severities.

The Hypothesis Behind The Cartilage Formation

The skeletal tissue regeneration requires specific mesenchymal or stromal cells from the bone marrow-derived adult stem cells. The adult stem cells pass through a transformation stage, where they first become cartilage, and bone tissues later. It is a natural and an automatic process of the stem cells to turn into cartilage, and then enter the ‘hypertrophic’ state. In this specific state, it spontaneously becomes bone tissues. The same state follows during the cartilaginous tissues after a fracture.

How It Works

The research team at The University of and University Hospital of Basel showed that cartilage formation is possible using mesenchymal stem cells. However, the process must adhere to the embryonic development of articular cartilage under the influence of certain molecular processes. In order to achieve the cartilage formation, the technique must restrict the signaling pathway of a certain protein Bone Morphogenetic Protein or BMP.


Further, the scientists highlighted the influence of two highly BMP receptor inhibitors in the whole process. When cultured in a microfluid platform, it is possible for them to form cartilage by blocking the effects of the inhibitors. In addition to this, with a blockage for a short span of time, the cartilage can be developed both in a mouse and the lab models.

Cells Based Models

This discovery is a good sign in the way of disease modeling. At the same time, it opens up new and advanced perspectives for the regenerative medicines and therapies for cartilage formation. Thereby, it focuses on the methods to manipulate tissue engineering for the development of any organ tissue during embryonic cartilage formation.

Last of all, using a certain molecular process, we can control the movement of progenitor and adult stem cells.

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April 23, 2018

Stem Cells: Treating Heart Disease With Umbilical Cord Blood

April 23, 2018 2

Treating Heart Disease With Umbilical Cord Blood

So far, we have enough evidence that the stem cells derived from the umbilical cord blood have the potential to do the magic. The magic is nothing, but in the form of regenerative medicines and therapies, that could help us combat a range of chronic diseases. Now, the researchers at the American Heart Association has once again brought us good news for the patients with cardiovascular issues. The insight of their research has been published in the medical journal Circulation Research.


Until now, we have to use invasive procedures to cure the patients with heart failure complications. But, the latest findings focus to aid in the development of noninvasive therapies using the umbilical cord. By using the therapy, it will be possible to make improvements in the heart muscles and make changes to the quality of the life.

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The  Concern Over The Disorder
heart failure stem cells

When the heart muscle cannot have the ability to pump blood effectively, it is known as heart failure. Nearly 37 million people globally are suffering from this heart disease. We have too many medical advances, still, we cannot treat people with heart complications. And a huge number of patients die every year despite being diagnosed with heart failure symptoms. So, the finding of the study is useful for us to get rid of the disorder.

The Elaborate Finding Of The Research

The trial showed a huge potential in favor of the patients taking part in the clinical trials. As many as 30 patients with lower to moderate level of heart failure complications participate. They aged between 18 to 75. Before these patients could receive intravenous infusions of umbilical cord-derived stem cells, they all had minimal drug therapy. The donors for the trials had full-term developed placentas from which the umbilical cord has been derived. Some of the patients received placebo also to determine the efficacy of the stem cells.
stem cell heart transplant

Consequences Of The Stem Cell Therapy As Compared To The Placebo

  • The patients had an improved life with a flexible capacity to pump blood to the heart and back to the whole body.
  • The quality of life has been
  • There was no side-effect, which is a quite common post any stem cell transplants. This apart, no sign of alloantibodies, or what we know by immune complexes was not detected so far.
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Umbilical cord stem cells did not show any potential though, the current studies are quite promising. We could no longer worry about the adverse effects of the cardiovascular complications, from now onwards. As is with intravenous umbilical cord stem cells, they are easily available, and accessible. Therefore, they raise more positive hopes for us. They are free of all incumbrances as we generally find in case with embryonic stem cells. Since they do not cause any immune complexes, they are a great scientific tool for the scientists for medical advances.

Why Choosing Umbilical Cord In Place Of Drug Therapy?

Such discovery is a way of living life better for many patients with cardiovascular symptoms. Earlier we have many instances which showcase that drug-based therapy is ineffective in case of heart diseases. They are not able to offer maximum benefit to alleviate the heart failure conditions. And that’s being one of the leading causes of patients’ concer, they opt for different invasive therapies. There are heart transplantations and ventricular mechanical assist device therapies, which often prove to be quite pricey for the patients.  

“The finding of the study is quite promising for us, as they could pave the way to develop non-invasive and promising new therapy for the patients with cardiovascular complications,” said the study correspondent author Fernando Figueroa.

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April 20, 2018

Stem Cell Summit:Ways To Improve Anti-CD19 CAR-T Cell Performances

April 20, 2018 0

Why Should We Look Beyond Anti-CD 19 CAR-T Cells? 

In the recent stem cell summit, we had so many strategies to improve the quality of stem cell transplants and make them successful. One of such strategies undertaken in the January Summit, held in Florida raises a concern over the performance of CD19 and finds pathways to improve its efficacy to target solid tumors.


The success of clinical studies on the efficacy of modified T cells garnered our hopes in the development of novel therapeutic treatments. We have witnessed that modification of chimeric antigen receptors (CARs) have been able to defy the cytotoxicity of tumors in many clinical studies. Engineered CD19 CAR-T cells being active in inducing anti-inflammatory immunity against B-cells malignancies, these cells are participating in the development of cancer adoptive immunotherapy.
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However, the hurdle in its way seems to be its ineffectiveness to combat solid tumors. We can find several factors that work against various approaches of these modified T-cells. The first one being the neoplasm activity of the microenvironment, which does not allow CAR-T cells to survive and reach the tumor surface. The host’s defensive mechanism becomes ineffective due to the useless anergic status developing from the ambiguous interactive communication amongst tumor components, stromal and immune cells.


Amidst these confusions, what pathways we should take to improve the performance of CD19 CAR-T cells? Or Should we look beyond some other immunotherapy to treat solid tumors?
stem cell research car-t cells

Efficacy Of CD19 CAR-T Cells

Anti-tumor efficacy of anti CD19 CAR-T cells has been expressed in children and adults through many clinical studies. T-cells can express its anti-immunotherapy properties against a series of B-cell acute lymphoblastic leukemia and other B-cell malignancies. We have two anti-cancer immunotherapies infused with anti-CD19 CAR-T cells named YESCARTA and KYMRIAH. Both these drugs are useful in suppressing B-cell expressions.


While this antigen CD19 CAR-T cell is capable of treating many B-cell malignancies, it is ineffective to even target solid tumor cells. Why so?

Factors Behind CD19 CAR-T Cells Being Inefficient In Solid Tumor Control

Its poor efficacy against malignant epithelial cells is due to the lack of capacity to target specific antigens in the microenvironment. Its inability to target active splice variant of epidermal growth factor receptor (EGFR), causes the growth of solid tumors and creates a hostile nature for its survival.

Ways To Improve Antigen Anti-CD19 CAR-T Cell Performances

While this immunotherapy fails to provide a positive result for the patients with solid tumors, other antigens like anti GD-2 CAR-T cells have shown some promises to treat different malignant conditions in clinical trials. Therefore, we can demand more clinical trials which can bring forth the introduction of anti-cancer immunotherapy using antigens.
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By using IL-2 support and increasing the number of cells for the ACT in melanoma, we can achieve a positive result for patients with solid tumors. Simultaneously, the physical barriers created by epithelial and mesenchymal cells need to be restricted to prevent ill effects of the cytotoxic functions of the solid tumors. And to effectively increase its efficacy against solid tumors, its persistence, eruption in the environment and tumor homing should be increased.

At the same time, if this antigen underperforms despite some changes, we should look beyond this. A recent study showed that BCMA targeted CAR-T cells can effectively perform on tumor-specific cells to stop further spread of the diseases. Many clinical trials have shown promises that this antigen could provide adequate relief from multiple myeloma.

So, we can rest assured that clinical studies and research could bring us effective CAR-T cells based immunotherapy in order to combat multiple malignancies and myeloma in future.

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April 12, 2018

Mesenchymal Stem Cell Therapy to Increase the Survival Rate in HLHS

April 12, 2018 0

Mesenchymal Stem Cell Therapy to Increase the Survival Rate in HLHS

Mesenchymal stem cell therapy seems an appropriate answer to the severities of HLHS disease. The congenital heart defects hypoplastic left heart syndrome (HLHS) does not allow babies to survive more than an average of five years after the birth. For the heart surgeons, it is one of the most challenging and complex forms of heart disorder to treat using surgeries and heart transplant.

Hypoplastic Left Heart Syndrome

The disorder leaves us with an incomplete developed left ventricle in the heart, which takes a key role in pumping blood to the lungs. As per the Centers for Disease Control and Prevention, every year 960 babies are exposed to this disorder, and if left untreated the outcome is always fatal.
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In normal, when we have healthy hearts, the right ventricle does not have to work hard to supply deoxygenated blood to the lungs from the body. The left ventricle, on the other hand, uses a greater level of strength to pump resupplied blood back to the body. However, with HLHS, the right side of the heart has to take the double workloads, as well as maintaining the blood circulation to both lungs and body. So, when the stress is too much for the right side of the heart, the heart fails to work and causes the baby to die.

Type of Treatments

HLHS requires three types of surgeries in order to be treated completely- the first one performed at the birth,  the second one at 4 months of age and the final one at the age of 2 or 4. However, it does not always promise to offer a curative treatment as patients with this disorder are more likely to die even after a heart transplant.
stem cell transplant for babies

Since open heart surgeries or transplant are not providing promising results, the only curative treatment option appears to be the stem cell therapy


We have more instances that support the use of stem cell therapy in the treatment of HLHS in babies. In a more recent incident, surgeons in Maryland injected the cells derived from bone marrow of the donor into the heart of baby Autumn Brown with HLHS. The four-month baby Autumn is now a part of the stem cell study with 10 babies at the  University of Maryland Medical Center. Both Wayne Brown and LeeAnn Janes, Autumn’s parents are hopeful for a better outcome of the clinical trial for their baby. As Autumn ’s mother wants nothing more than her healthy life, she expects that she will lead a normal life with implanted stem cells in her heart. More instances show that she is improving and will meet her relatives soon. Janes said, “I could see the stem cells as creating a super heart.”
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The Finding of Their Study

The research carried out by Dr. Kaushal had an objective of boosting or regenerating the right ventricle in patients with HLHS so that their right heart could pump blood strongly. Their research also showed that babies with implanted mesenchymal stem cells are doing well.
hlhs stem cell transplant babies

MSCs have allogenic properties, so they can easily expand in the culture, and are a perfect source for the trail. MSCs prove to be effective in restoring heart functions in a clinical trial, which focuses the same features for HLHS too. These cells are capable of forming heart muscles and restraining the heart muscle from dying.


The finding of the study suggested that the same techniques will work for patients with hypoplastic left heart syndrome too.

We have earlier seen that stem cells provide a great potential to regenerate heart muscles. So it is believed that the result of the study will work better in case of pediatric patients too. That’s because hearts in younger individuals have better opportunity to grow as opposed to the older patients since the body is still in the development phase.

So, we can hope this novel therapy will one day improve the health of little patients who have a vulnerability to mortality.

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I am an avid health Blog writer. I write for several health sites and blogs, do thorough research work and accumulates all essential information that makes the blogs informative and enhances their value.