2018 - Stem Cell Therapy Treatments

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August 24, 2018

Stem Cell Therapy-Regeneration Of Neural Stem Cells For Spinal Cord Injuries

August 24, 2018 0

Stem Cell Therapy-Stem Cells Derived Neurons May Cure Spinal Cord Injuries

Stem Cell Therapy For Spinal Cord Injury: Over the past few years, stem cells have evolved as a promising therapeutic source, traversing those previous concepts of inability to treat irreparable neural injuries.stem cell therapy for spinal cord, spinal cord injury treatment with stem cell therapy.

The anecdotes of medical history are an example of why modern medicines were not able to treat the issues of spinal cord injuries, leaving thousands of patients paralyzed and causing them the loss of functional abilities.stem cell therapy for spinal cord, spinal cord injury treatment with stem cell therapy

Why Spinal Cord Injuries Still Untreatable With The Modern Medicinal Therapy?

There are various reasons that contribute to the paralysis of these patients and influence the restoration of their physical movement and independent physical control. One of the key reasons why spinal cord injury cannot be treated as no catalysts work properly to cultivate new neurons, responsible to develop and strengthen the spinal cord. embryonic stem cell treatment therapy for spinal cord injury, stem cell therapy for spinal disorder.
treating spinal cord injuries
Besides that, regenerating new tissues for the damaged spine requires a donor to implant the newly developed tissue, which is not feasible for many for being a costly surgical affair. Other than this, the regenerative stem cell therapy for the new spinal tissue development did not see much success. Hence, foraying into this venture for the researchers is quite risky.

However, stem cell-based therapy seems quite promising for spinal cord injuries at this point of time.

In order to activate the motor functions, it requires addressing the regeneration of the corticospinal tract (CST) in the rodents. CST is an important region of the spine that develops the communication process with the brain. Upon failing to establish a communication with the brain, it leads to loss of motor functions. Well, this is an important aspect of treating spinal cord injury, which is still infeasible for many researchers. stem cell therapy for spinal cord treatment, stem cell for spine injuries,
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However, researchers have claimed to reverse the negative effect of the spinal cord injury that inhibits the growth of new neurons.  They have discovered a new method of inducing ‘generic’ human stem cells that can differentiate into stem cells more specific to the spinal structure.

New Technique Of Cell-Based Therapy For Spinal Cord Injury 

Earlier, multipotent cells, a kind of progenitor cell-based CST graft trials were in use to address spinal cord injury. For not being true stem cells, the strategy did not yield potential results.

However, these days, human embryonic stem cells or induced pluripotent stem cells are used as a key source for this health complication. These cells are reprogrammed to regenerate CST, and also other needed spinal cord tissues required to replace the damaged spinal tissues in the spinal cord.
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At the same time, the study focused that these neural stem cells are more capable of developing different types of neurons via differentiation process. Although this finding works in a certain eligible model, it raises hopes that stem cell-based neurons are capable of growing damaged or missing spinal cord tissues.
In the study, the researchers influenced stem cells to regenerate ‘customized spinal graft’ for transplantation in the subjects.

How The Researchers Proved The Effectiveness Of The Study?

The CST based grafts were well integrated with pre-existing spinal tissues, consisting of various inputs related to neural connections specific to the location. This reprogramming of the neural system aimed at influencing peripheral functions like movement under normal conditions. However, it was only possible if the grafts were able to make a differentiation between the dorsal and ventral parts of the spine, responsible to send communication signals to the brains in an average healthy spine.

The study was successful to establish the capability of the grafts to facilitate this behavior in the models, and restore their motor skills.

This new discovery is awaiting the approval to be used in the real world treatment.

Since it is a successful discovery of the regeneration of neural stem cells for spinal cord injuries; we can look forward to use the same technique to be used for other spinal disorders too.


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August 21, 2018

Stem Cell Therapy Offers Treatment Options For Cartilage-Hair Hypoplasia

August 21, 2018 1

Stem Cell Therapy Transplant Offers Successful Treatment Options For Cartilage-Hair Hypoplasia

Stem cells are not a host of news that most people are eager to know about it. But, there are still a few clinical approved pieces of research that have been showing some great efficacies regarding the clinical uses of stem cell research. There are many pending clinical applications of the stem cells for a wide range of conditions, including cancers, which are under the process of the clinical trials. stem cell therapy for hair hypoplasia, stem cell transplant for hair hypoplasia.

However, so far whatever has been approved for stem cells in clinical trials, they have been proved the potential to treat and offer effective results to genetic syndromes with evidence of immune deficiency. As with many such immune deficiencies, stem cell transplants prove to be beneficial in treating cartilage-hair hypoplasia or (CHH), also referred to as metaphyseal chondrodysplasia. The transplantation aims at improving health conditions victimized by the blood stem cell or immune system related health conditions like cancers and many degenerative diseases. The treatment procedures cure the ailment by restoring the blood systems of immunodeficiency diseases. hair hypoplasia treatment with stem cell therapy, stem cell therapy for cartilage-hair hypoplasia.

Provided cartilage-hair hypoplasia or metaphyseal chondrodysplasia, stem cells offer the best treatment opportunities while improving the health conditions and also the quality of the life of the sufferers.
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Cartilage- Hair Hypoplasia And Its Effects On Life
Cartilage-Hair-Hypoplasia

Cartilage- Hair Hypoplasia or CHH is an autosomal recessive disease, and also a type of bony dysplasia characterized by a little to no hair with short fingernails, short dwarfism physical stature due to immunodeficiency along with different immune defects, including a varied degree of combined humoral immunodeficiency. stem cell therapy for bone marrow transplant,

It means this inherited disease results in bone deformities including a weak and beak immune system. An average of 15% of the population that suffers from this rare genetic disease has some different characters such as fine, sparse hair, in which alopecia affects the hair growth largely and causes hair losses with no natural hair pigmentation.

Patients with CHH may have different symptoms that feature normal hair growth for some, while others feature normal immunology. However, the occurrence of this immunodeficiency disease emphasizes the immunological defects, which inhibits the cellular immune response, especially CD4 cells. A short of chromosome 9 causes a gene mutation, leading to the occurrence of this disease. People with CHH have 86% grip of the immunodeficiency, which later may attract the harsh outcomes as a result of severe combined immunodeficiency, increasing the vulnerability of life-threatening infections.
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Primary Symptoms Of CHH

In general, CHH has a wide range of symptoms, including
• Bony structural abnormalities including spinal cord defects
• Inadequate while blood cells
• Short limbs and
• Anemia
Referred to as an inherited autosomal recessive, this rare hereditary disease is generally passed through both the parents, yet none of the parents show any signs of the disease.

    Complications Of CHH

    • Autoimmune ailments
    • Infection vulnerability
    • Immune system cancer, such as lymphoma
    • Blood cancer, such as leukemia
    • Gastrointestinal complications and
    • Skin cancer

    Various Treatment Options For Cartilage-Hair Hypoplasia

    Patients suffering from CHH with related immunodeficiency complications can get treatment choices like vaccinations and immunoglobulin replacement therapy, and antibiotics for infections.
    For more severe conditions like the severe combined immunodeficiency, the stem cell therapy transplant using hematopoietic stem cells can offer a potential and effective result. Sometimes, the treatment procedure involves bone marrow transplant and blood transfusion.

    Outcome Of Hematopoietic Stem Cell Transplant

    A previous survey by the European Bone Marrow Transplant group in 2010, reported a successful stem cell transplant for 16 CHH patients. The transplant was successful as it improved the life expectancy of the 63% of the participated patients, making them the long-term survivors for around seven years.
    At the same time, the survival rate of the patients has been increased by 80% using HLA matched donor stem cells. It is to note that HLA matched donors increase the success rate of the stem cell therapy transplant as compared to unrelated matched donors.
    Since stem cell transplant is a hope against the immunodeficiency disease like Cartilage- Hair Hypoplasia, we need more advanced research for stem cell to be available for every patient at an ease.

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    August 17, 2018

    Check Out How Anti-Aging Stem Cell Therapy Help With Frailty

    August 17, 2018 0

    Anti-Aging Stem Cell Therapy Could Help With Frailty

    Every living organism is made up of stem cells, and they are great elements that hold the secrets to staying disease free of various chronic ailments and even staying young. This is what scientists claim for stem cells that they are the only way to everlasting health and wellness.
    So, while talking about doing away with frailty, it is highly dependent on stem cells as per the researchers. Yes, aging can be inhibited, so can be its effects on health using the stem cell therapy or tissue engineering therapy.
    In recent two human trials, the results showed some promising avenues regarding anti-aging stem cell therapy that reverses the effects of age-related frailties and other conditions. And much to your surprise, the consequences of the stem cell trials on humans are absolutely safe and effective.
    Anti-Aging Stem Cell Therapy

    How Anti-Aging Treatment Breathes Its Life Through Research?

    There have been many examples of how stem cells have been saving many well-known faces from their woes as well as transforming them cosmetically. We have the likes of Kim Kardashian, David Beckham, and Simon Cowell to opt for stem cell therapy to hold onto their youthful appearances for long. This is completely a cosmetic purpose to look beautiful and flawless forever. This apart, many popular sports personalities like Diego Costa, Angel de Maria, Kobe Bryant and even Tiger Woods chose stem cell therapy to get rid of their injuries, yet they are rumors. Well, it is the magic of stem cell therapy that has restored their sports career on a perfect track, or else we would have seen an end to their great forms in no time.

    Hence, we can be sure of the efficacy of the anti-aging stem cell therapy treatments.
    Studies also threw light on some recent successful developments of stem cells targeting the anti-aging factors.
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    A discovery of protein in older mice reinstates the aging process by suppressing the graying of hair and also enhancing their physical fitness. Another study proves that using fecal transplant; it is possible to increase the lifespan of some fish. Hence, all these hints at how potentials are stem cell therapies to restore aging and reverse its effects.

    Key Stem Cells To Trigger This Anti-Aging Benefits In Humans

    Mesenchymal stem cells are a type of adult stem cells. These cells are great elements to be a huge target for scientists for disease modeling. These cells are a center of attraction as their disease-fighting capabilities are high against more than eighty chronic pathological conditions from cancer to cardiovascular diseases.
    Now, this cell type is a target in the human trials to assess its anti-aging strength so as to defy the effects of frailties on adult populations. And now, the trial is awaiting a nod from the FDA to clear the final stage of approval.
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    The whole research has been detailed in a guest editorial in The Journal of Gerontology.

    How The Therapy Works To Restore Aging?

    As we age, our muscles tend to lose its elasticity as well as regeneration capabilities. Hence, we are likely to fall ill and become vulnerable to different diseases. It is stem cell therapy that suppresses the aging effects.
    Stem cells are cultured in the lab under controlled conditions. They are then injected into the damaged area to replace those cells. The cells go to the damaged site and adjust to the area, while the local cells release ‘distress signal’. The cells proliferate and mature into cells just like the specific cells of the site and regenerate new tissues and organs. The stem cell therapy is powerful to replenish the damaged cells by proliferation and make one look youthful and rejuvenated.
    It is not only anti-aging treatment that gives us a relief from frailty, but also from a wide range of debilitating ailments at an affordable rate. So, let us hope that the stem cell therapy could bring advanced healthcare for all very soon. 

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    August 15, 2018

    Stem Cell Therapy To Repair Human Joint Injuries With Crocodile Cartilage

    August 15, 2018 0

    Stem Cell Therapy To Repair Human Joint Injuries With Crocodile Cartilage

    Joint pain, mostly due to arthritis is the leading cause of worldwide disability, leaving twice as many as people bedridden for their entire life. With no possible cure in sight so far, the treatment possibilities of arthritis and its various types now can see the lights at the end of the tunnel because of the stem cell therapy. Earlier stem cells have been proved to be a boon for a varied chronic and debilitating diseases like that of leukemia, neurodegenerative disease, Parkinson’s disease, dementia and multiple sclerosis and not to mention the problems related to the eyes.
    Treating joint injuries along with different forms of arthritis is now even easier with 3D printing in combination with stem cell therapy and crocodile cartilage. Doesn’t it sound so weird? Perhaps yes, it is not impossible though.
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    Arthritis And Its Treatment Procedure
    stem cells for knee injuries

    Arthritis needs a closer detection of the injury to identify its pathophysiology through arthroscopic surgery. The process of the surgery enables the identification of the injury in the cartilage, facilitating the treatment of joint injuries using the arthroscope. Arthroscope involves a small device, which needs to be inserted into the injured joint through a small incision. Although it is a non-invasive joint surgery, it does yield painful results for the victims as the recovery period is quite lengthy.

    However, this little painful consequence is envisioned to be overcome using the 3D printing technology in compliance with stem cell therapy and crocodile cartilage. This new treatment procedure will help in finding a therapeutic for joint injuries due to arthritis.
    The joint injuries and arthritis are highly prevalent among sports athletes, who cannot join the fields once they undergo the procedure of the arthroscope. Now, this process could be a passé and thanks to Dr. Pardraig Strappe for discovering a novel process to diagnose the ailment and treat without any minimal pain along with a faster recovery result.

    How The Processes Of 3D Printing Work?

    Dr. Strappe with his team of researchers from Center Queensland’ University is eyeing to activate the human immune response by using crocodile cartilage with its growth factors and turning off the proteins. The process actually turns adult stem cells into bio-print cartilage explants for the transplantation into the injured or damaged human joints. Hence, it is proof that crocodile cartilage could be a great resource to turn stem cells into human cartilage and cure joint injuries or arthritis.

    Since the crocodile cartilage turns human adult stem cells sourced from bone marrow or other cells into cartilage, they can alleviate the joint pain and distress in many, especially in adult populations. Along with the development of cartilage, it seems possible to promote cartilage repair too.
    After a knee injury, it is likely that the joint develops a crack or fissure in the knee or joints, which cannot heal on its own due to lack of the blood supply system in the cartilage. However, as cartilage develops a crack, it eventually becomes a hole, this needs a treatment.
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    So, by using a 3D printing, we can have an exact graph of the injury that mimics the hole in the 3D printing, making it clear for the surgeons to fill the gap easily.

    Why Crocodile Is The First Choice?

    The crocodile has a larger amount of growth promoting compounds like proteoglycan in the cartilage. And the compound is highly available near the rib cage. Hence, the resource for joint injuries or arthritis is immense. This is the first focused report conducted by the Commonwealth Scientific and Industrial Research Organization (CSRIO), which makes it possible for a crocodile to have varied movement procedure using their articulating joints. So, this cartilage is useful to turn stem cells into active cartilage and to be used as a human cartilage in the joints.
    Now, the focus will be on the availability of the procedure that will relieve the tensions of arthroscopic surgery in no time, and enable us to live a happy life without the fear of disability.

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    August 09, 2018

    Stem Cell Therapy Model To Treat Diseases Of The Nervous System

    August 09, 2018 0

    Stem Cell Model To Treat Diseases Of The Nervous System

    It wasn’t until the discovery of stem cell therapy that the treatment of neurodegenerative disease was believed to be an impossible event. Hence, any disease pertaining to the nervous system, including cancer, congenital disorders, and degenerative diseases such as Parkinson’s disease and Alzheimer’s disease and multiple sclerosis including traumatic diseases were among the incurable diseases. However, the tissue reparative and regeneration potentials of stem cells had removed the roadblocks to expanding the treatment scopes of replacement therapy for scientists.

    Stem Cell Therapy Disease Modeling

    Based on thousands of clinical studies and research works on stem cells and its disease treating potentials, the stem cell therapy transplantation proves to be life-saving for many chronic and life-threatening diseases like cancers, amyotrophic lateral sclerosis. Now, a new research has proved that monitoring the mechanisms of various nervous system diseases like Parkinson’s disease and Alzheimer’s disease is possible with the stem therapy cell model. Previously, this is what has been an unimaginable phenomenon for many.
    Now, treating any disease related to the nervous system is easier, since scientists for the first time have discovered a novel method to monitor the disease using stem cells.
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    This disease modeling is helpful in determining the etiologies of the diseases and find treatment options for varied neurodegenerative diseases like Parkinson’s, Alzheimer’s and sclerosis. A team of scientists at City of Hope National Medical Center has discovered a model of stem cells to evaluate the disease types of the nervous system. This disease model is helpful in suppressing the actions of Alzheimer’s disease, including various neurodegenerative diseases.

    In order to find the efficacy of the disease modeling, the scientists monitored Alexander disease- a similar kind of a nervous system disorder like that of Alzheimer’s.

    Stem Cell Therapy Model To Detect The Mechanism Of Neurodegenerative Disease

    In order to identify how neurological disease works and hinders one’s mental strength, they examined Infantile Alexander’s Disorder- pathology demyelinating leukoencephalopathy- a hereditary disease which expresses itself in the early childhood.
    For Alexander disorder, its mutation in glial cells known as astrocytes promotes the growth of the myelin sheath by inhibiting the cell type precursor. The myelin sheath protects the nerves and fosters the nerve impulse transmission in the brain.

    In astrocytes, dwells a gene called ApoE4, responsible to prompt the growth of Alzheimer’s disease and other neurological disorders. The only way to suppress the mechanism of Alzheimer’s and Parkinson’s is to maintain the operation techniques of astrocytes in Alexander, and hence the cure of Alexander along with Alzheimer’s and Parkinson’s is possible.
    It was to find how gene mutations called GFAP in astrocytes suppress the action of the myelin sheath. To find this, GFAP mutation was collected from a patient’s brain.
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    Further Observation Of The Study

    Based on the gene mutation, a stem cell therapy model was built to identify the growth of Alexander disease and find ways to develop and evaluate therapeutic interventions for nerve related disorders. When the data of the patient with Alexander disease was observed, both the results hinted at protein deposits known as Rosenthal fibers.
    With CRISPR/Cas9 gene editing techniques, the mutation of GFAP astrocytes was corrected. This helped reduce the mutations in GFAP of the patient’s brain, and also the protein deposits.

    How to cure Disease Alexander

    Further examination of the study found that stem cells of the patients with Alexander disease the mutation in astrocytes cause the secretion of protein CHI3L1 GFAP, suppressing the growth of myelinization and causes neuroinflammation.
    Therefore, any therapeutic that inhibits the functions of CHI3L1, can help reduce the symptoms of Infantile Alexander and even cure it and other degenerative diseases like Alzheimer’s and Parkinson’s disease.
    We can hope for the best to come up in the near future and cure our conditions of neurological disease so that we can lead a quality life in the society.

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    July 24, 2018

    Stem Cell Therapy To Cure Ischemic Heart Disease In The Patients

    July 24, 2018 0

    Stem Cell Therapy To Cure Ischemic Heart Disease In The Patients

    How do we breathe air? Our heart takes a major role in enabling us to breathe oxygenated blood supplied to our body pumped by its two ventricles. But, when there is a heart failure, this normal function of our body does not occur, resulting in complications of breathing and even deaths.  As is with many etiologies of the heart failure, ischemic heart disease is one of the leading causes of heart failure. Having its similarity with the myocardial infractions, it causes major health hazards.

    Heart Failure a major health complication

    With regard to this, stem cell therapy could improve the survival rate of the patients suffering from ischemic heart disease or myocardial infarction. However, prior to stem cell therapy, different types of therapeutics and clinical procedures have been used, but they did not show any promising outcome and contributed to the mortality rate. In addition, current therapies delay the progress and do not foster any repair and regeneration of cardiac tissues of the damaged myocardium.
    stem cell therapy for heart disease
    This is one of the key reasons to look out for the assistance for a heart transplant, a costly medical option, leaving so many frustrated over the financial burden. However, ever since the inception of the stem cell therapy in the year 1988 came forward, the stem cell-based therapy is proving to be a magical therapeutic method for a range of chronic diseases including heart failure.

    The Role Of Stem Cell Therapy In Heart Failure Improvement

    So far, stem cell therapy has proven to be an effective and promising treatment for the damaged cardiovascular tissues or myocardial tissues. We had enough evidence of bone-marrow-derived mesenchymal stromal cells, including induced pluripotent stem cells to regenerate myocardial tissues and cure heart failure in the animals and also different clinical trials. Ever since animal models and clinical trials have been successful to showcase the efficacy of cell-based therapies, application of stem cells thereby is widespread in the clinical settings to treat the conditions of heart failure.

    Various Types Of Stem Cell Therapy For Ischemic Heart Disease

    Mesenchymal Stromal Cells
    As linked to a heterogeneous population of fibroblast, mesenchymal stromal cells are a part of multipotent cells, which are able to differentiate into different types of lineages like osteocytes, chondrocytes, and adipocytes. All these lineages foster the development of different tissues like bone, cartilage, adipose, and muscles. At the same time, many clinical trials were successful to show the potential of mesenchymal stromal cells to be differentiated into different types of cardiac tissues like endothelial cells and cardiomyocytes. Apart from bone marrow, these cells are easily isolated from various sources like umbilical cord, placenta, and adipose tissues. With special characteristics like surface markers, they are easily used for the treatment of cardiac injury because of their ease of isolation process.

    Embryonic Stem Cells

    Embryonic stem cells belong to the earlier form of cells known as blastocysts. They are multipotent and equipped with self-renewal capacity to differentiate into many cell types. The different clinical trials had shown that human embryonic stem cells can easily differentiate into cardiomyocytes under a certain culture condition in the lab. It fosters the improvement of cardiac functions and also heartbeats. This therapy is not averse to challenges as well. The retention of injected hESCs is subject to pro-survival factors to ensure their adaptability to the injured site. And hence, using these cells, it is possible to increase the rate of their growth factor to the site.

    Adipose-Derived Stem Cells

    They are different from bone marrow-derived stem cells. The isolation process of these tissues from the subcutaneous adipose tissues is quite a less expensive procedure for the treatment of myocardial infarction. These cells are heterogeneous and contain hematopoietic stem cells with different transcription factors, making them an easy product for the cardiomyocyte regeneration in vivo.
    Heart failure and myocardial infarction are a major public health issue. With a rapid advancement in the clinical procedure of stem cell therapy, we can make it easily available for the treatment of this debilitating disease, and reduce the morbidity and mortality across the world.

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    July 19, 2018

    Suppressing Glioma Stem Cells- A New Hope For Brain Cancer Patients

    July 19, 2018 1

    Suppressing Glioma Stem Cells- A New Hope For Brain Cancer Patients

    The glioma cancer stem cells-the culprit behind the occurrence of an aggressive and adamant type of primary brain cancer is called Glioblastoma multiforme. Its aggressiveness due to inbuilt defensive traits helps them maintain their resilience against any type of therapy and medications. Despite success in the preliminary treatment processes, the disease recurs and eventually becomes untreatable. In addition, its metastatic characteristic makes it possible to spread all over the body and foster recurrences. This is why, with more than 25% of young individuals and children are diagnosed with this disease every year, making it a leading cause of cancer-related deaths in America.

    It is now devised to develop a new method to impact its defensive nature and eliminate the cancer stem cells from the root to stop the further destruction in the body.
    stem cells for brain tumor

      A Brief Insight Into The Disease

      The brain cancer Glioblastoma multiforme (GBM) occurs in the central nervous system and gradually attacks the neural system. Since the brain does not have much capacity to repair itself, it fails to respond to the treatment exhibited from outside. Therefore, this type of cancer can do a rapid damage to the adjacent body part. Based on this comprehensive understanding, researchers at Virginia Commonwealth University devised a new method to work on the defensive mechanism of the cancer stem cells.

      The pathway aimed at turning them inactive so that their maintenance behavior can be curtailed and a novel therapeutic could be discovered to cure this debilitating disease.
      The whole finding of the study is made available on the website of PNAS. It sheds light on the mechanism of glioma stem cells, through which they prevented cell death and spread.
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      What Makes The Glioma Stem Cells Prevent The Effects Of Surgery, Radiation, And Chemotherapy? 

      It is the high-grade gliomas, which tend to make the brain cancer stem cells resistant to various cancer-killing treatment methods. And this is the reason why these cancer cells in the brain tumors are so aggressive. Another key reason for the survival of glioma stem cells is their capacity to detach from the anoikis. We can recognize anoikis as apoptosis known to be a cell death, occurring when the extracellular matrix denies a cell’s existence within its proximity.

      This process is known as ‘scaffolding’ fosters the renewal of stem cells through differentiation and homeostasis.  However, glioma stem cells remain unaffected, and they can easily avoid anoikis using a protective mechanism autophagy, enabling them to recycle and eat their own cellular detritus.

      How To Curb Their Resistance To Various Therapeutic Ways?

      Scientists found that the MDA-9/Syntenin a type of gene is responsible to provide protection to the protective autophagy of glioma stem cells. In addition, the gene causes other types of cancer to be aggressive. Therefore, scientists came to a conclusion that an inhibition of MDA-9/Syntenin is a possible way to suppress the defensive mechanism of glioma stem cells.
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      Technique Used To Curb Their Resistance

      Not only does MDA-9/Syntenin monitor autophagy mechanism, but in compliance with epidermal growth factor receptor (EGFR) signaling, this gene reduces toxicity and destruction in glioma stem cells. Since, EGFR has been linked to encouraging the growth, differentiation, and proliferation of tumor, tumor growth see a surge in different types of cancer using its signaling.

      Further, scientists proved that in the absence of the gene, EGFR signaling cannot perform independently. In addition, there is a relation between protective autophagy, resistance to anoikis and also the gene MDA-9/Syntenin. So, if the connection is dismantled, it is possible to restrict the protective and defensive mechanism of glioma stem cells, and further restrict the tumor development in the brain.
      The whole study carried out on a mouse model is now being devised to find ways to treat other cancer types too.
      So, by suppressing the gene expression of MDA-9/Syntenin, it could lead to discovering many improved cancer treatments in the future.

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      July 16, 2018

      Treatment Of Bowel Disease Using Stem Cell Therapy

      July 16, 2018 2

      Stem Cell Therapy Is The Answer To Bowel Disease

      How will it be to form a new regenerative therapy using stem cells to have control over gut microbes? This would open up many doors to tracing the roots of various diseases caused due to gut microbes. This is how scientists at the University of Toronto are devising a tailor-made gut-inhabited microbe to release drugs when instructed.
      The team led by associate professor David McMillen is on their quest to develop regenerative medicine therapeutics to discover etiologies of intestinal diseases. In order to do so, they are eyeing to put an engineered bacterium into the gut to detect the source of different diseases occurred by the gut bacteria.

      The Proposed Idea Of The Interdisciplinary Project

      Intestinal stem cells are like progenitor or hematopoietic stem cells with an ability to proliferate and differentiate, and they are well-endowed with self-renewal capacity. Hence, when there are a wear and tear in the intestinal tissues, they can easily manage the damaged tissues through self-renewal capacity. Taking this into account, the scientists are collecting intestinal stem cells for regeneration in a culture dish, aiming to improve their capacity of natural healing power in the body, and also foster the tissue regeneration for replacement.
      stem cell therapy for bowel disease

      Physiological Process Leading To Bowel Or Intestinal Diseases

      The discoveries of science have us going surprised by its amazing traits and functions inside the body. Much to our surprises, nearly 100 billion cells confront an exit every day through an intestine as a result of extreme wear and tear, which occurs due to the digestion process in the body. However, due to these lost cells, we do not suffer any extreme health condition unless something goes wrong with the entire physical systems. We must thank to stem cells to replenish all these lost cells in collaboration with the intestines, and lend their assistance in repairing damaged tissues. However, when stem cell therapy cannot provide its support for tissue repair, we can suffer from a range of diseases from inflammatory bowel disease to cancer.

      The prevalence of inflammatory bowel disease or IBD is quite high among the children aged fewer than six. Adults are also not safe from various types of IBD like Chron’s disease or ulcerative colitis, impacting heavily on the quality of the lives of every person suffering it.
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      What Makes IBD Act So Gruesomely?

      Replacing damaged or malfunction cells in the intestines are the normal functions of stem cells. However, the cells in the intestinal lining do not get any replacement, it is to create a hole in the gut, and as a result, the leaky gut cannot digest food properly, detoxify the wastes and ward off microbes from the gut. Therefore, the gut becomes vulnerable to developing IBD.

      Ways to curb IBD’s effects on health?

      The microbiome- the resident gut bacteria, often considered as a neglected organ is one of the crucial parts of our bodies to help us tackle many diseases by boosting our immune system. Hence, scientists inserted engineered gut microbe into the lining of the gut wall so as the manipulated microbe can detect an inflammation and possibly help find ways to treat and even cure IBD.
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      In addition, the gut bacteria are wired to secreting an enzyme called muramyl dipeptide (MDP), which makes a connection with receptor NOD2, residing in the stem cells. As per reports, this enzyme works in compliance with this receptor to influence intestinal stem cells to divide and create new cells for lining repair.

      It is likely to manipulate the gut bacterium to increase the production of MDP enzyme so as to curb the inflammation in the intestine. It is possible to trigger human receptors to urge stem cells so that they can double the healing of the gut lining and cure Crohn’s disease.
      From the study, we can hope for a fruitful approach in the future, which can better health using stem cells and the regenerative therapeutics and medicines. The days are not so far when we can achieve relief from these debilitating conditions with ease. And credits remain at the foot of stem cells. 

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      July 13, 2018

      Stem Cell Technique Holds Promises For Regenerative Therapy

      July 13, 2018 0

      Stem Cell Technique Holds Promises For Regenerative Therapy

      We know how regenerative therapy has proven a boon for medical applications in the real-time clinical settings. The basic of the tissue engineering is nothing, but the cell-based techniques using stem cells. Although there are different sources to harness stem cells, one of the primary sources to derive stem cells is adipose stem cells.

      Key Functions Of The Regenerative Therapy

      Stem Cell Regenerative Therapy
      Stem cells work at the cellular level by following proliferation and division techniques. When there is a wear and tear in the cells, stem cells tend to repair that damage and heal itself at a faster rate.  The healing of the particular cells is undertaken when the DNA confirms the damage in the particular site and instructs stem cells to use its reparative potentials.  Hence, the malfunctioning of the DNA interrupts the healing and regeneration process by stem cells, and no cure actually takes place. In that particular case, when our physical system loses its potential to heal and regenerate tissues following the stem cell proliferation and division, the entire works rest upon the regenerative therapy.

      The regenerative therapy is a cell-based therapeutic, aiming at repairing and regenerating damaged tissues in the body. 
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      When our body becomes matured, a significant trade-off mechanism is built. A matured cell tends to lose its capacity of the division, but it can specialize later. Muscle or tissue regeneration is necessary for life to sustain. Muscle cells, for example, can only contract since they are able to contract only. If all our muscles were specialized, we would have lost our potentials to proliferate, and as a result, our tissue cannot regenerate. Hence, this is a huge life-threatening risk for us. However, our body does not have to follow this risk as we tend to store a small number of stem cells, which are able to divide and replace damaged tissues.

      The Application Of Stem Cells For Regenerative Therapy

      Due to the specialized character of the stem cells, these elements are widely used for the tissue regeneration using the harvesting method from the donors. So, once they are harnessed, they are implanted in the patients to enable the tissue engineering procedures. However, this process does not work for those, who are infected with genetic degenerative disorders. People suffering from this ailment cannot donate their stem cells as they are useless for causing repair in the natural manner.
      Hence, it is highly deemed fit to collect stem cells from someone healthy.  And therefore, the collected tissues once implanted are able to regenerate a healthy and populated tissue in the affected area.
      At the same time, the collected stem cells can be manipulated to engineer into a required tissue in a petri dish in a lab. In this case, the cells are reprogrammed to mimic the normal tissue functioning so that they can divide and specialize into the tissue for the transplant. Burn injuries, for example, need harvested stem cells to grow the tissues in the lab for an implant. The process of tissue regeneration for burn victims are referred to as skin grafts.
      Therefore, stem cells can provide immense advantages for medical research and applications to treat genetic disorder as well as different physical ailments. We are thankful to the scientists that they are quite knowledgeable about the use of stem cells in the regenerative therapy. 

      The Primary Source Of Stem Cells To Aid Regenerative Therapy

      It is not hidden to any of us that regenerative therapies are based on stem cell clinical techniques. There is a wide range of sources like adult mesenchymal stem cells, embryonic stem cells to harvest stem cells. However, the most accessible source is the fat-derived adipose tissue to harness stem cells for the procedure of regenerative therapy. Since these fat cells are huge resourceful, stem cells can be collected at any time from any part of the body.
      Read-
      Its promising characterization to foster the growth factor in vascularization, it is ideal for the regenerative tissues. Hence, we can see its abundant use in the field of cosmetic surgery too.
      Let’s hope for a huge growth of regenerative therapy for prospective medical advances, so as to improve the quality of life of the mass.

      stem cell research, regenerative medicine, stemcell, mesenchymal stem cells, stem cell transplant, stem cell injection, adult stem cells
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      July 11, 2018

      Stem Cell Therapy Treatment For Adamant Cancer Cells

      July 11, 2018 0

      A Novel Stem Cell Therapy Is Up To Good For Adamant Cancer Cells

      Every one of us knows what functions does our immune system offer to our bodies. It builds a sturdy defensive mechanism against all the foreign intruders, making us immune to a wide range of diseases. Not only does it protect us from a common cough and cold, but it has a huge potential to restrict the glares of some forms of cancers in our bodies too.

      How The Immune System Works?

      The immune system works as a warrior as it offers the first line of defense for us.  The key component of the immune system is a white blood cell, otherwise known as a macrophage. It is for the macrophage, we are protected round the clock as it keeps strolling around our various systems and combating those wicked, infected and cancerous cells.
      stem cell therapy for cancer cells

      Why Cancer Cells Become So Aggressive?

      Have you ever thought if that white blood cell works round the clock in our bodies, how do we fall victims to those hard-to-treat cancer cells?
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      That’s because cancer cells have a protein called ‘CD47’ on their surfaces, while a protein called SIRPalpha binding to macrophages works in alliance with ‘CD47’ protein. The combination of these proteins helps cancer cells to avoid the clutches of the macrophages by emitting a signal ‘don’t eat me’, and thus, cancer cells escape their engulfing grasp.

      However, this unique ability of cancer cells can be outperformed by a novel stem cell therapy designed by scientists at the Stanford University. Researchers Irv Weismann and his associate Ravi Majeti developed the new stem cell therapy through a preclinical development trial using funds from the California Institute of Regenerative Medicine (CIRM) and Forty Seven Inc. The clinical trials backed by the Stanford University raise hopes to deactivate the performance of CD47 and develop new therapies for acute myeloid leukemia (AML), solid tumors and also colon cancers.

      How The Therapy Appear To Be Affective On CD47?

      The stem cell therapy consisting of the two monoclonal antibodies such as 5F9 and Rituximab can bind to the surface of CD47 and SIRPalpha and deactivates the signal “don’t eat me” from cancerous stem cells. Therefore, cancer cells can no longer exert their functions to impact the immune system. Interestingly, the cancer cells are infused with cancer stem cells, and therefore they can proliferate at a faster rate and cause tumor relapses. 

      The Results Of The Therapy

      The therapy along with antibodies and Rituximab resulted in a drop of remission by 50% for patients with relapse in the clinical trials. The trials are still underway, but it is hard to say that this therapy offers a greater efficacy to kill cancer cells by blocking CD47 protein signal only.
      Scientists found that blocking the action of CD47 is not everything to make macrophage fight aggressive cancer cells. Despite macrophages killing cancer stem cells, some stubborn cancer cells can easily cloak themselves and remain active in the body.
      Even though ‘don’t eat me’ signal is turned off, the cancer cells seem to follow some other signal to survive.
      And therefore, the high levels of MHI or Major Histocompatibility Complex class I became an essential tool for the detection of cancer cells’ resistance to macrophages. It guides another immune system in the body to detect the happenings in the body. When the cells of another immune system like T and B cells find something disturbing, they can destroy them.

      However, MHI class I protein binds to a protein known as LILRB1 on macrophages and protect cancer cells by triggering ‘don’t eat me’ signal. Thereby, when either of the functions of MHI Class I or LILRB1’s signals is turned off, the macrophages get their strength back and fight cancer cells all over again. The entire observation was carried out in a petri dish or an animal model.
      The therapy can prove to be effective to fight the stubborn tumor growth and cancer stem cells in the real clinical settings one day. The wait is there only for the clinical trial so that it can get the success on the participants as well.

      stem cell therapy, stem cell transplant, bone marrow transplant, myelofibrosis cure, stem cell therapy for cancer, pluripotent stem cell therapy, breast cancer, american cancer society
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      July 05, 2018

      Stem Cell Therapy Lending Its Hand To Cure Heart Impairment

      July 05, 2018 1

      Stem Cell Therapy Lending Its Hand To Cure Heart Impairment

      Stem cell therapies have been doing the rounds since long because of their life-saving potentials and best medical applications for chronic diseases and also disease testing. As with many other health complications, cell-based therapies are showing satisfactory results for heart disease also. According to a study published by the American College of Cardiology’s 65th Annual Scientific Session, a novel stem cell therapy can improve long-term health complications associated with severe and final stage cardiac disorder.

      Cardiac Complications

      So, what does happen when your left ventricle of the heart start malfunctioning? It stops pumping blood to your body, preventing all the necessary physical functions at its best. Gradually, it contributes to many complications, which later weakens your cardiac functions.  Sometimes, the condition increases the chances of sudden cardiac death due to loss of cardiac functions. This is one of the natural reasons for most adults in the U.S to lose their lives. We cannot refer to sudden cardiac death as heart failure, but it is a condition, occurring during the heart attack or failure. However, stem cell-based therapies or therapeutics can facilitate the cardiac treatment and enhance the living and quality of life of the victims at ease.
      cardiac function
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      While the therapeutics offer multiple clinical benefits for the cardiac patients, they are promising as well to heal wounds in the cardiac system. Maybe, this is surprising for you, but it has happened recently, which claims to heal the 11-year-old boys wound in the left ventricle and resurrects him to get back to his normal life with a little ability to perform tasks.

      How Stem Cell Helped The Boy To Lead A Normal Life?

      It has been all because of the stem cell procedures, which enabled Braden Heckendorn to fight tough battles with his life over the past few years and lead an active life today.
      In December 2013, Braden Heckendorn was playing with a pellet gun in his relative’s house. Meanwhile, the gun malfunctioned and the pellet shot through his armpit and finally hit his left ventricle. He was down with no sense for twenty minutes, while his father, Bruce Heckhendorn was doing cardiopulmonary resuscitation on him. This helped him revive but he suffered a major heart stroke after 96 hours. He was admitted to the hospital with a range of health issues like sight difficulties, inability to talk and walk. Since he had developed brain injuries; the doctors had limited options to provide better clinical benefits to him. When all the methods failed, Braden’s parents turned to a stem cell institution to collect a match for their child and approached them to develop tissues for him. Braden Hackendorn gave his blood sample to one of the stem cell organizations, which was manipulated later to turn into mesenchymal stem cells in a petri dish in a lab.

      Coaxing stem cells to turn them into cardiac cells would have not possible five years ago in the U.S. And in the near future, it seems nearly impossible as the FDA has approved only cord blood-derived stem cells to be used for the clinical applications and drug development.
      Read-

      However, he received the treatment for his injured heart from a stem cell organization in Mexico.
      With his heart not functioning properly for 22 minutes after that accident, he became paralyzed.  But, after the transplant, he is perfectly alright and showing signs of improvement. He can use his hands to eat and dress himself.

      Since mesenchymal stem cell therapy has been successful to cure his heart ailments; we can be hopeful to receive this type of therapy in abundance in the future too. And one day, there will be no more apprehension regarding chronic diseases and cancers too.

      stem cell transplant, heart transplant, stem cell heart surgery, stem cell therapy for heart disease, stem cell research, congestive heart failure, heart attack symptoms, symptoms of heart disease
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      July 01, 2018

      Muscle Stem Cells Could Help Old People With Work

      July 01, 2018 0

      Curbing Mutations In Muscle Stem Cells Could Help Old People With Work

      Our ability to perform certain functions is dependent on how we exert the muscular techniques. As long as we are young enough, the muscular capabilities remain active and aid in the execution of different functions. But as we grow older, the muscular functions fall short of our expectations and cannot offer a greater level of strength to perform any tasks. This is something which occurs due to an unprecedented number of mutations in the stem cells of muscles. The mutations impair the regeneration of cells, and inhibit the further progress of muscle functions; as a result, it deprives older individuals of their physical ability to perform tasks. This new study has been brought to the light by researchers at Karolinska Institute.

      The study has raised a hope to develop a new drug or medication to help build stronger muscles no matter how older we become.
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      Reasons Behind Aging Muscles And Its Deformity

      For everything which hinders our capacity to work properly while we age, is mainly for muscle stem cells or satellite cells. These cells do not exert any muscular functions as they remain dormant in the muscle tissues. However, they are likely to proliferate and specialize to replace damaged tissues or organs when influenced by the external forces like physical workout or injuries. This is a well-grounded restorative function of muscle stem cells, but these functions reduce too with age and it does not advocate for any tissue regeneration through self-renewal capacity. As a result, the agility and strength of aging muscles deteriorate and decline. Therefore, the study clearly focuses on how there is a distinct relation between aging muscle and stem cells.
      stem cells of muscles
      Until now, there has been no clear indication why aging muscles lose its flexibility to perform a task. But, this is now clear as the study has successfully established how mutations in muscles play a key role in hindering the task performing ability to age muscles as compared to their younger counterparts.

      How The Study Validated Muscle Elasticity?

      In the study, they found that a healthy 70-year-old could collect as high as 1000 mutations in each of their muscle cells. These mutations cannot inhabit every cell, and the cells without these mutations are better protected and providing an adequate performance capability to a person. The study was successful to focus that with age, this strength of the cells also declines for the natural cell division process. As a result, an aged muscle loses its capacity to repair DNA. This leads to a novel pathway for scientists to discover a new method to influence the muscle with a newly developed drug.

      How The New Therapy Is Devised?

      In order to invent a new drug to foster the DNA repair and inhibit the impairment of muscle elasticity and functions, scientists turned to single cell DNA sequencing methods. The single cell genome sequencing helped them identify how each muscle stem cell does have a direct influence from a complex mutational burden. At the same time, the number of these mutations is two-three times higher in the cells of aging persons than younger counterparts. This is the reason why younger individuals are more fit and active to perform their tasks with more flexibility and agility as they do not show any sign of higher number of mutations.

      In addition to this, the new drug development would also take into consideration the role of physical exercise to counteract the mutational influence on the muscle cells.
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      So, if researchers can find out a new trigger to reduce the influence of the mutational reactions in cells, it is possible to discover new workout programs for aging populations too. And we can expect healthy old people to lend their shoulders to increase the productivity of young individuals.

      stem cell therapy, stem cell of muscles,  joint disorder, knee arthritis, stem cell anti aging, stem cell knee repair, stem cell banking, cord blood banking, 
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      June 29, 2018

      Stem Cell Therapy To Prevent The Dilemma Of Female Hair Loss Anxiety

      June 29, 2018 1

      Female Hair Product To Prevent The Dilemma Of Hair Loss Anxiety

      The regeneration of damaged tissues or organs has achieved an advanced feat since the advent of stem cell therapies. Not only do these magic cells result in the development of better cell-based therapies for many chronic illnesses, they have created a new benchmark in cosmetic technology for physical modifications too. For the successful cell-based therapies with regard to cosmetology, the whole process takes long days of research and hard work to confirm their efficacies. In addition, the effectiveness of any new product must go through some clinical trials so as to establish their usefulness to the users and validate their safety for use.

      Hair Loss And Its Effects

      So, when an extreme hair loss raises your concerns about your look and your stance in the perspective of the social spectrum, you lose your heart. If you are really careful and want a solution to this issue, stem cell therapy can find you a way out.
      stem cell female hair loss
      Although you are not alone whose life is affected by this gruesome physical flare-up, about 40 million men and 21 million women are facing extreme hair loss problems in the United States. For the perfect solutions, they do really need an immediate hair regeneration therapy involving stem cells as all the current available hair growth options prove ineffective. An average of 7% of affected people do not show any interests to find any treatment for this, or their general reluctance prevents them from choosing a hair transplant surgery. Therefore, the scenario to improve the hair loss problems is not so promising for many due to these reasons.

      Nonetheless, women can at least find a way out of their problem, and they do not need to go for any hair transplant procedure. A San Diego based regenerative medicine company- Histogen has received an approval from the Food and Drug Administration (FDA) to apply for the Investigational New Drug (IND) for the clinical trial. This process is paving the way for them to carry out a study on their proposed female regenerative product.
      Read-

      Prospects of the Product

      The company is aiming at introducing a component to this female product known as Hair Stimulating Complex (HSC660). The product is an injectable substance, which can work after its application onto the scalp. Since the company is associated with tissue or organ engineering with their products, this new hair product also aims at stimulating the users’ stem cells to reengineer tissues or stimulate their hair follicles to trigger hair growth in women.

      Key Components Of The Formula

      The component of the product is manufactured at their bioreactors using cell media condition to focus on their growth factors. HSC 660 compound contains different growth factors, including follistatin, keratinocyte growth factor (KGF) and vascular endothelial growth factor (VEGF). Follistatin triggers the division of hair follicle stem cells, while the two other growth factors foster hair growth as well as stimulate dormant hair follicles.

      The formulation of the product contains complex biological ingredients enriched with naturally secreted growth factors and proves to be effective as well for alopecia- an autoimmune condition causing hair loss in patches.
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      As the product has shown its efficacy in their bioreactors, now they are approaching to go on a clinical trial on women with HSC660.
      In addition to the promising aspects of the product, another recent study showed to be effective to solve difficult-to-treat hair conditions like temporal recession hair loss in younger populations of 40-plus years old both men and women.
      With a green signal from the FDA, there is a possibility for us to stave off this problem soon and trigger new hair growth.

      stem cells to regrow hair, female hair growth disorder, stem cell therapy for hair loss, hair transplant, hair loss treatment, stem cells to reverse baldness, stem cell hair regeneration
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      June 28, 2018

      Revival Of Heart Cells Using Stem Cell Therapy

      June 28, 2018 0

      Revival Of Heart Cells Using Stem Cell Therapy

      In recent times, stem cell treatments have opened up a broad spectrum for many health conditions, especially for genetic disorders, immunodeficiency disorders, and spinal cord injuries and not to mention- the heart disease.
      When we talk about the complications involved with cardiovascular disease, it makes sense to find out more about how stem cells are effective in the treatment of this disorder.

      The Normal Heart Cells And Its Normal Function

      Our heart is capable of renewing its cells from as early as our fetus stage. During this time, the heart grows by increasing their cells.  We can see a steady growth of heart cells as we grow up. There is generally no change and decrease in the total number of heart cells in a healthy and uninjured adult human heart.
      Revival Of Heart Cells
      According to the studies, the renewal capacity of heart cells has already been inherent in the heart from its fetus phase. This modest level of heart cell growth proliferates with the times but slows down when injured or goes under basal conditions.
      In addition, our heart tends to grow its cells at every stage like adolescence, middle age and old age. Once reaching 50, we retain 55 percent of heart cells from our birth, while 45 percent of cells develop later in life.
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      The growth of new heart cells following an injury

      Do you believe the possibility of heart’s revival at a fast pace following an injury? In most cases, the rate of new cell growth to the injured heart is higher as compared to the heart remaining at a normal condition. It is not that you have to believe only those said words of some individuals. The statements have a validation of different research and studies, which focuses on its revival at steady speed after an injury. All this is possible due to the different therapies involving infusions, injections, and various cells derived implants like stem cell therapies. They prove beneficial for the injured hearts. The transplanted cells are effective in regenerating or renewing the injured heart cells in compliance with the existing heart cells. In addition, the new growth of heart cells in injured tissues in the cardiovascular structure is solely dependent on various sources of cells as well as their capacities.

      Let us remove the veil from it and have it in a more clear way. As soon as the new heart cells are injected using bone marrow-derived stem cells, the retention remains at a low degree. However, the bone marrow-derived stem cells infused with CD43 proteins on their surfaces, become more effective for the renewal of new heart cells as their retention increases about tenfold. This protein takes a key role in migrating new stem cells into the heart muscles at a fast pace.

      Disagreement about Stem Cells’ Effectiveness

      Though the renewal of new heart cells or proliferation is possible with transfusions and stem cell transplant, the functional improvement of the newly transplanted stem cells into the heart is rarely achievable.  And hence, researchers are finding other ways to make the whole process of renewal of new heart cells workable for the patients. Therefore, they believe that the heart cells from early stem cells can be beneficial to regenerate new heart cells and contribute to blood pumping functions as well as the heartbeat in sync with the pre-existing heart muscle.

      Successful Clinical Trials

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      While there is a disagreement regarding the role of stem cell transplant in promoting an effective cardiac function, a large number of successful clinical trials can prove their usefulness. These trials can prove promising for us as they can bring the real and effective results of stem cell transplant to be used on humans from the lab setting with an approval.


      stem cell heart transplant, stem cell therapy for heart, stem cell therapy for heart failure, stem cell therapy heart surgery, stem cell therapy heart repair, stem cell transplant for hair loss, stem cell therapy for joint disorder, stem cell therapy for skin treatment, stem cell therapy for cancer vaccines
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      I am an avid health Blog writer. I write for several health sites and blogs, do thorough research work and accumulates all essential information that makes the blogs informative and enhances their value.